探讨糖尿病肾病患者尿微量白蛋白与尿酸及血清胱抑素C相关性.docVIP

探讨糖尿病肾病患者尿微量白蛋白与尿酸及血清胱抑素C相关性 　　DOI：10.16662/ki.1674-0742.2017.25.001 　　[摘要] 目的 探?糖尿病肾病患者的尿微量白蛋白与尿酸及血清胱抑素C的相关性。方法 随机选取该院2015年1月―2016年3月收治的糖尿病肾病患者50例为研究组；另选取健康者50名为对照组。采用多功能检测仪检测两组血清中mAlb、Cys C水平。结果 对照组mAlb（11.79±1.64）mg/L、Cys C（0.75±0.18）mg/L、UA（200.12±12.56）μmol/L；研究组mAlb（14.70±1.84）mg/L、Cys C（1.75±0.56）mg/L、UA（467.12±12.78）μmol/L；研究组患者血清mAlb、Cys C明显高于健康患者组成的对照组（PⅢ期Ⅱ期Ⅰ期（P0.05）。结论 尿微量白蛋白与尿酸及血清胱抑素C可反映肾脏系统损害程度，具有极高的诊断与应用价值。 　　[关键词] 糖尿病肾病；尿微量白蛋白；尿酸；血清胱抑素C 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）09（a）-0001-03 　　Investigation of the Correlation between Urinary Microalbumin and Uric Acid and Serum Cystatin C in Patients with Diabetic Nephropathy 　　ZHANG Min1， PAN Ting2 　　1.Department of Clinical Laboratory， Ophthalmology Hospital of Lianyungang， Lianyungang， Jiangsu Province， 222000 China； 2.Department of Clinical Laboratory， Donghai County People’s Hospital， Donghai， Jiangsu Province， 222300 China 　　[Abstract] Objective This paper tries to investigate the correlation between microalbuminuria and serum uric acid and serum cystatin C in diabetic nephropathy patients. Methods 50 patients with diabetic nephropathy in this hospital from January 2015 to March 2016 were randomly selected as the study group. 50 healthy peoples were selected as the control group. The levels of mAlb， Cys C in serum of two groups were detected by multi-function detector. Results In the control group， mAlb was （11.79±1.64）mg/L， Cys C was （0.75±0.18）mg/L， UA was （200.12±12.56）μmol/L； in the study group， mAlb was （14.70±1.84）mg/L， Cys C was （1.75±0.56）mg/L， UA was （467.12±12.78）μmol/L； the serum mAlb， Cys C in the study group were significantly higher than the control group of healthy peoples（P 　　[Key words] Diabetic nephropathy； Microalbuminuria； Uric acid； Serum cystatin C 　　糖尿病肾病（diabetic nephropathy，DN）是糖尿病并发症之一，临床早期DN病情无显著表现，常规检测中很难发现，DN后期临床症状显著，肝肾肝功能明显下降，严重影响患者日常生活中质量，因此对DN病情的前期诊断与治疗显得尤为重要[1-3]。现阶段尿微量白蛋白（urinary microalbumin，mAlb）是诊断DN早期主要依据，胱抑素C（Cystatin C，Cys C）可作为反映肾小球过滤情况的重要标志