探讨慢性脑供血不足患者血清同型半胱氨酸水平同其颈动脉硬化之间相关性.docVIP

探讨慢性脑供血不足患者血清同型半胱氨酸水平同其颈动脉硬化之间相关性 　　【摘要】 目的 分析慢性脑供血不足患者血清同型半胱氨酸（Hcy）与颈动脉硬化的关系。方法 38例慢性脑供血不足患者作为观察组， 选取同期体检健康者36例作为对照组， 比较两组血清Hcy水平， 分析观察组血清Hcy与?i动脉硬化的关系。结果 观察组患者血清Hcy（18.2±3.6）μmol/L明显高于对照组的（10.7±3.4）μmol/L， 差异具有统计学意义（P0.05）； 颈部血管彩色超声检查显示， 38例观察组患者中20例（52.6%）有颈动脉粥样硬化斑块。按照有无颈动脉粥样硬化斑块分组， 20例有颈动脉粥样硬化斑块的患者血清Hcy（21.3±3.8）μmol/L， 18例无颈动脉粥样硬化斑块的患者血清Hcy为（14.1±4.0）μmol/L， 两组比较差异具有统计学意义（t=5.689， P=0.0000.05）。结论 血清Hcy与慢性脑供血不足患者颈动脉硬化之间关系密切， 可能对脑卒中风险有预示作用。 　　【关键词】 慢性脑供血不足；同型半胱氨酸；颈动脉硬化 　　DOI：10.14163/j.cnki.11-5547/r.2017.05.013 　　Investigation of correlation between serum homocysteine level and carotid atherosclerosis in chronic cerebral circulatory insufficiency patients BAI Yan-jun， WEN Nuan， LIU Jing-xia. Jilin Provincial Hospital of Neuropsychopathy， Siping 136000， China 　　【Abstract】 Objective To analyze relationship between serum homocysteine （Hcy） level and carotid atherosclerosis in chronic cerebral circulatory insufficiency patients. Methods There were 38 patients with chronic cerebral circulatory insufficiency as observation group and another 36 healthy people at the same period as control group. Comparison was made on serum Hcy levels between the two groups to analyze the relationship between serum Hcy and carotid atherosclerosis in the observation group. Results The observation group had obviously higher serum Hcy as （18.2±3.6） μmol/L than （10.7±3.4） μmol/L in the control group， and their difference had statistical significance （P0.05）. Carotid color Doppler ultrasound examination showed 20 cases （52.6%） with carotid atherosclerosis plaque among 38 cases in the observation group. They were divided by whether with carotid atherosclerosis plaque or not into two groups. 20 cases with carotid atherosclerosis plaque had serum Hcy as （21.3±3.8） μmol/L， which was （14.1±4.0） μmol/L in 18 cases without carotid atherosclerosis plaque. The difference had statistical significance between the two groups （t=5.689， P=0.0000.05）. Conclusion Serum Hcy is closely related with car