拉贝洛尔治疗妊娠期高血压疾病对母婴预后及血清Hcyhs―CRP水平影响.docVIP

拉贝洛尔治疗妊娠期高血压疾病对母婴预后及血清Hcyhs―CRP水平影响 　　【摘要】 目的：观察研究拉贝洛尔治疗妊娠期高血压疾病对母婴预后及血清同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）水平的影响。方法：选择本院2013年3月-2014年3月收治的200例妊娠期高血压患者作为研究对象，采用随机列表法将其分为观察组和对照组，每组100例。对照组给予常规治疗，观察组在常规治疗的基础上给予拉贝洛尔治疗。观察比较两组孕妇和胎儿的预后情况及两组治疗前后血清Hcy、hs-CRP水平的变化。结果：观察组子痫发生率低于对照组，但比较差异无统计学意义（P0.05）；观察组新生儿窒息、胎儿窘迫、产后出血及剖宫产发生率明显低于对照组，比较差异均有统计学意义（P0.05）；两组治疗后血清hs-CRP、Hcy水平均低于治疗前，比较差异均有统计学意义（P0.05）；治疗后，观察组hs-CRP、Hcy水平低于对照组，比较差异均有统计学意义（P0.05）。结论：拉贝洛尔治疗妊娠期高血压效果显著，可有效的避免不良的母婴预后结局，降低孕妇血清Hcy、hs-CRP水平，值得临床推广应用。 　　【关键词】 拉贝洛尔； 妊娠期高血压疾病； 母婴预后； 血清同型半胱氨酸； 超敏C反应蛋白 　　【Abstract】 Objective：To observe the effect of Labetalol on the serum Hcy，hs-CRP levels and prognosis of mother and child when using in the treatment of hypertensive disorders in pregnancy.Method：200 cases of pregnancy induced hypertension patients in our hospital from March 2013 to March 2014 were selected and randomly divided into the observation group and the control group，100 cases in each group.The control group was given conventional treatment，the observation group was treated with Labetalol on the basis of conventional therapy.The prognosis of the maternal and fetal，the levels of serum Hcy and hs-CRP before and after treatment were observed and compared between the two groups.Result：The incidence rate of eclampsia in the observation group was lower than that in the control group，but the difference was not statistically significant（P0.05）.The incidence rates of neonatal asphyxia，fetal distress，postpartum hemorrhage and cesarean section in the observation group were lower than those in the control group，the differences were statistically significant（P0.05）.After treatment，the levels of serum Hcy and hs-CRP in the two groups were all lower than those before treatment，the levels of serum Hcy and hs-CRP in the observation group were lower than those in the control group，the differences were all statistically significant（P0.05）.Conclusion：Labetalol in the treatment of hypertensive disorders in pregnancy can receive significant effect