支气管哮喘急性发作期患者白细胞介素及超敏C反应蛋白水平变化及临床意义.docVIP

支气管哮喘急性发作期患者白细胞介素及超敏C反应蛋白水平变化及临床意义 　　[摘要] 目的 探讨支气管哮喘急性发作期患者白细胞介素（简称IL-17）及超敏C反应蛋白（hs-CRP）的水平变化及临床意义。 方法 选择90例哮喘急性发作期患者为研究对象，从哮喘急性发作期患者中随机选择46例患者作为哮喘缓解期组，选择48例健康人群为对照组，对比三组血清IL-17、hs-CRP水平，比较哮喘急性发作期患者治疗前后血清IL-17、hs-CRP水平，分析血清IL-17、hs-CRP水平与患者肺功能的关系。 结果 三组患者的血清hs-CRP、IL-17水平存在显著差异（P=0.0000）；急性发作期组患者的血清hs-CRP、IL-17水平明显高于缓解期组、对照组（P 0.01）；缓解期组患者的血清hs-CRP、IL-17水平高于对照组（P0.01）。治疗后哮喘急性发作期患者的血清hs-CRP、IL-17水平明显低于治疗前（P0.01）。血清hs-CRP、IL-17水平与FEV1占预计值%呈负相关；血清hs-CRP、IL-17水平与FEV1/FVC呈负相关；血清hs-CRP、IL-17水平与ACT呈正相关。 结论 哮喘急性发作期患者血清IL-17、hs-CRP水平明显增高。哮喘患者血清IL-17、hs-CRP水平与肺功能关系密切。 　　[关键词] 支气管哮喘；急性发作期；IL-17；超敏C反应蛋白 　　[中图分类号] R562.25[文献标识码] B[文章编号] 1673-9701（2014）18-0023-03 　　 　　Change and clinical significance of IL-17 and hypersensitive c-reactive protein level of bronchial asthma patients with acute episodes 　　QIN Yihua 　　Department of Medicine II, the People’s Hospital of Maonan City in Guangdong Province, Maoming 525011，China 　　[Abstract] Objective To study change and clinical significance of IL-17 and hypersensitive c-reactive protein level of bronchial asthma patients with acute episodes. Methods A total of 90 cases of asthma patients with acute phase were selected as the research objects of this study. 46 patients in asthma patients with acute episodes were randomly selected as asthma remission group. 48 cases of healthy crowd were selected as control group. Serum IL-17 and hs-CRP levels in three groups were compared. Serum IL-17 and hs-CRP levels of asthma patients with acute phase before and after treatment were compared. Relationship between serum IL-17 and hs-CRP levels with pulmonary function in patients were analyzed. Results Serum hs-CRP and IL-17 levels of three groups of patients had significant difference（P=0.0000）; Acute phase serum hs-CRP and IL-17 levels of patients were obviously higher than that of remission group and the control group （all P 0.01）; Serum hs-CRP and IL-17 levels of patients in remission group were higher than the control group（P0.01）. After