早发型重度子痫前期患者血清高密度脂蛋白和尿酸水平变化及临床意义.docVIP

早发型重度子痫前期患者血清高密度脂蛋白和尿酸水平变化及临床意义 　　[摘要] 目的 探讨早发型重度子痫前期（EOSP）患者血清高密度脂蛋白（HDL）和尿酸（UA）水平的变化及其与围产儿预后的关系。 方法 选择48例EOSP患者作为观察组，另选择同期在我院行产前检查的健康孕妇41例作为对照组。分别采血检测HDL、UA、尿素氮（BUN）和肌酐（Scr）水平，并观察两组围产儿的预后。 结果 观察组血清HDL、UA、BUN和Scr水平均显著高于对照组（P0.01）。观察组的新生儿体重明显低于对照组（P0.01），而早产、胎儿窘迫的发生率及围产儿死亡率则明显高于对照组（P0.05）。 结论 EOSP患者血清HDL、UA水平升高与EOSP的发病及围产儿的不良预后有关。 　　[关键词] 早发型重度子痫前期；高密度脂蛋白；尿酸；围产儿 　　[中图分类号] R714.24 [文献标识码] A [文章编号] 2095-0616（2017）14-59-03 　　Changes of serum high density lipoprotein and uric acid levels in patients with early onset severe preeclampsia and its clinical significance 　　YANG Ping HE Xia 　　Department of Obstetrics and Gynecology， Baiyun District Hospital of traditional Chinese Medicine， Guangdong， Guangzhou 510470， China 　　[Abstract] Objective To explore the changes of serum high density lipoprotein and uric acid levels in patients with early onset severe preeclampsia and its relation with perinatal prognosis. Methods 48 patients with EOSP were selected as observation group. In addition， 41 healthy pregnant women who underwent prenatal care in our hospital during the same period were selected as control group. HDL， UA， urea nitrogen （BUN） and creatinine （Scr） levels were measured by blood sampling. Prognosis of two groups of perinatal children was observed. Results The serum levels of HDL， UA， BUN and Scr in the observation group were significantly higher than those in the control group （P0.01）. The neonatal weight of the observation group was lower than that of the control group （P0.01）. The incidence of premature birth， fetal distress and perinatal mortality were higher than those in the control group （P0.05）. Conclusion Elevated levels of serum HDL and EOSP in patients with UA are associated with the incidence of EOSP and the adverse prognosis of perinatal infants. 　　[Key words] Early onset severe pre eclampsia； High-density lipoprotein； Uric acid； Perinatal 　　妊娠期高血?杭膊。?HDCP）是妊娠期特发疾病，子痫前期为其常见类型，是导致孕产妇及围产儿死亡的原因之一。早发型重度子痫前期（early onset severe preeclampsia，EOSP）是指