替米沙坦联合钙离子拮抗剂治疗糖尿病肾病并发高血压临床研究.docVIP

替米沙坦联合钙离子拮抗剂治疗糖尿病肾病并发高血压临床研究 　　[摘要] 目的 分析替米沙坦联合钙离子拮抗剂治疗糖尿病肾病并发高血压病的临床疗效。方法 随机选取该院2013年5月―2015年1月收治的120例2型糖尿病肾病合并高血压患者，随机分为对照组和观察组各60例，对照组的患者口服替米沙坦片；观察组患者则加用钙离子拮抗剂拉西地平片，两组均连续治疗2个月。监测治疗前后血压、肾功能水平变化，计算有效率。 结果 对照组患者的有效率达到71.6%，明显低于观察组患者的有效率90%（P0.05）；观察组患者的血压、肾功能改善情况优于对照组患者（P0.05）。 结论 替米沙坦联合钙离子拮抗剂药物治疗糖尿病肾病并发高血压疗效确切，利于改善患者的血压及肾功能，值得临床应用并推广。 　　[关键词] 替米沙坦；钙离子拮抗剂；糖尿病肾病合并高血压 　　[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-0742（2015）08（b）-0129-02 　　[Abstract] Objective To investigate the clinical curative effect for treating diabetic kidney disease complicated with hypertension patients with telmisartan combined calcium antagonists. Methods 120 diabetic kidney disease complicated with hypertension patients were randomly divided into a control group of 60cases and an observation group of 60 cases from May 2013 to January 2015. Patients in the control group were treated with telmisartan tablets； while patients in the observation group were treated with calcium antagonists on the basis of control treatment， 2 months for treatment. The paper was focus on monitoring the blood pressure and kidney function before and after treatment， and calculating the effective clinical treatment. Results The efficiency for patients in the control group was 71.6%， which was lower than that of the observation group 90% （P0.05）；The improvement of blood pressure and kidney function of the patients in the observation group were better than that in the control group， and the level of DBP， SBP， Scr， 24 Upro and UAER were lower than that in the control group （P0.05）； Conclusion The therapy has curative effect，which is good to improve the blood pressure and kidney function， is worth of wide application in the clinical practice. 　　[Key words] Telmisartan； Calcium Antagonists； Diabetic kidney disease complicated with hypertension 　　糖尿病肾病是糖尿病患者临床常见的微血管病变，亦是发展至中晚期常见的并发症之一，患者以渐进性肾功能损害、蛋白尿、水肿、高血压等为典型特征，可使肾小球发生病变，使血压升高，重则引发肾功能衰竭，是糖尿病患者致死的重要危险因素。该研究笔者以替米沙坦联合钙离子拮抗剂对糖尿病肾病并发高血压病患者进行治疗，效果满意，现报道如下。 　　1 资料与方法 　　1.1 一般资