替罗非班在急性心肌梗死中应用效果.docVIP

替罗非班在急性心肌梗死中应用效果 　　【摘要】 目的：探讨替罗非班在急性心肌梗死（AMI）治疗中的应用效果，为临床上该病的治疗积累经验。方法：符合纳入标准的89例AMI患者，入院后按照抽签随机取样法将其分为对照组（43例）和观察组（46例）。两组患者均给予氯吡格雷、阿司匹林等口服及低分子肝素皮下注射，在此基础上对照组使用微量泵持续泵入肝素，1000 U/h，持续36 h，观察组使用微量泵持续泵入替罗非班，0.15 μg/（kg?min），持续36 h。观察比较两组患者的心电图改变、主要不良心脏事件发生率及不良反应发生情况。结果：给药前两组患者ST段下降、缺血导联数比较差异无统计学意义（P0.05）；给药后，两组患者ST段下降、缺血导联数均显著改善，且观察组改善显著优于对照组（P0.05）。结论：替罗非班能够有效调节AMI患者心电图变化，降低主要不良心脏事件发生率，并且安全性高，值得在临床上推广应用。 　　【关键词】 急性心肌梗死； 替罗非班； 有效性； 安全性 　　The Effect of the Application of Tirofiban in Treatment with the Acute Myocardial Infarction/LIN Chang.//Medical Innovation of China，2015，12（16）：070-072 　　【Abstract】 Objective：To investigate the effect of the application of Tirofiban in treatment of the acute myocardial infarction （AMI），and to accumulate experience for the clinical treatment of the disease.Method：89 patients who were in accordance with the inclusion criteria of AMI were randomly divided into control group （43 cases） and observation group （46 cases）.The patients in the two groups were given oral clopidogrel and aspirin tablets and the subcutaneous injection of low- molecular- weight heparin.Based on the treatment above，the control group used micro-injection pump to continuously pump heparin into the patients at the speed of 1000 U/hour which lasted 36 hours，while the observation group used micro-injection pump to continuously pump Tirofiban into the patients at the speed of 0.15 μg/（kg?min） which lasted 36 hours.The changes in electrocardiogram，the incidence of major adverse cardiac events and the occurrence of adverse reactions of the patients between the two groups were compared.Result：Before the medicine was given，the differences of the ST segment depression and ischemia lead number of the patients between the two groups had no statistical significance （P0.05），but after the medicine was given，the ST segment depression and ischemia lead number of the patients in the two groups improved a lot （P0.05）.Conclusion：Tirofiban can effectively regulate the changes in ele