曲美他嗪对PCI术相关心肌缺血再灌注损伤及 预后影响.docVIP

曲美他嗪对PCI术相关心肌缺血再灌注损伤及 预后影响 　　[基金项目] 国家自然科学基金H0206） 　　 　　[摘要] 目的 探讨曲美他嗪对经皮冠状动脉介入治疗（PCI）术相关心肌缺血再灌注损伤及预后的影响。 方法 选择94例择期PCI术冠心病患者，随机分为研究组和对照组，各47例，研究组在对照组常规治疗基础上于术前3d开始口服曲美他嗪至术后维持，比较两组手术前后血清cTnI、CK-MB、MDA、CRP水平，术后12个月随访心血管不良事件发生情况。结果 两组术后血清cTnI、CK-MB、MDA、CRP水平均显著升高（P ＜0.05），但研究组术后各时点血清cTnI、CK-MB、MDA、CRP水平均显著低于对照组（P ＜0.05）。经Kaplan-Meier生存曲线法计算，研究组和对照组术后12个月无心血管不良事件，生存率分别为85.23%和64.39%（P ＜0.05）。研究组患者无明显不良反应。 结论 曲美他嗪对PCI术缺血再灌注造成的心肌损伤有保护作用，可减少近期心血管不良事件发生，长期服用安全性好。 　　[关键词] 曲美他嗪；经皮冠状动脉介入治疗；缺血再灌注；心肌损伤；预后 　　[中图分类号] R541[文献标识码] A[文章编号] 1673-9701（2014）19-0004-04 　　 　　Effect of trimetazidine for PCI were related myocardial ischemia-reperfusion injury and prognosis 　　JIANG Liuxia1 FU Guosheng2 SHOU Ye3 　　1.Dispensary for Western Medicine, Zhejiang Chinese Medical University Third Affiliated Hospital, Hangzhou 310005, China; 2.Department of Cardiology, Sir Run Run Shaw Medicine Affiliated to Medical College of Zhejiang University, Hangzhou 310016, China; 3.Department ofFunctional Check, Zhejiang Provincial Tongde Hospital, Hangzhou 310000, China 　　[Abstract] Objective To investigate the effect of trimetazidine on PCI, myocardial ischemia and reperfusion-related injury and prognosis. Methods A total of 94 cases of coronary heart disease patients undergoing elective PCI were randomly divided into study group and the control group , 47 cases in the control group, the study group on the basis of conventional therapy before surgery 3d start giving oral trimetazidine to maintain postoperative two groups were compared before and after surgery serum cTnI, CK-MB, MDA, CRP levels and after 12 months follow-up of cardiovascular adverse events were observed. Results The postoperative serum cTnI, CK-MB, MDA, CRP levels were significantly higher (P ＜0.05), but the study group at all time points in the postoperative serum cTnI, CK-MB, MDA, CRP levels were significantly lower in the control group (P ＜0.05). The Kaplan-Meier survival curve method , the study group and the contro