柴胡疏肝散合六君子汤方治疗慢性乙型肝炎临床研究.docVIP

柴胡疏肝散合六君子汤方治疗慢性乙型肝炎临床研究 　　【摘要】 目的：观察柴胡疏肝散合六君子汤方对慢性乙型肝炎的临床疗效。方法：为将60例慢性乙型肝炎患者随机分为两组：对照组30例，以苦参素针剂肌肉注射，2ml/次，隔日1次，结合一般护肝药进行治疗；治疗组30例，在对照组治疗的基础上，加服柴胡疏肝散合六君子汤方，1剂/日，水煎分两次服用。两组均以180d为1个疗程。观察两组患者治疗前后临床症状、体征，肝功能、HBV-DNA、乙肝标志物的变化。结果：治疗组总有效率为93.3%，对照组为70.0%，两组比较，差异有统计学意义（P0.05）；两组患者治疗后与本组治疗前比较，谷丙转氨酶（ALT）、谷草转氨酶（AST）的恢复有统计学意义（P0.01），总胆红素（TBil）的恢复有统计学意义（P0.05）；治疗组与对照组治疗后比较，谷丙转氨酶（ALT）、谷草转氨酶（AST）及总胆红素（TBil）的恢复无统计学意义（P＞0.05）。治疗组HBV-DNA阴转率36.7%（11/30），HBeAg转阴率为23.3%（7/30），对照组分别为13.3%（4/30）和6.7%（2/30）。两组比较差异有统计学意义（P0.05）。结论：方柴胡疏肝散合六君子汤对改善慢性乙型肝炎临床症状，恢复肝功能，促进HBV-DNA、HBeAg转阴有较好的作用。 　　【关键词】 慢性乙型肝炎；柴胡疏肝散合六君子汤方；中医疗法 　　 　　 　　Six Gentlemen Decoction Chaihushugan Powder Treatment of Chronic Hepatitis B 　　Yang ShikuiYang Shangdong 　　（Qingzhou City, Shandong Province Peoples Hospital, Shandong Qingzhou 262500） 　　【Abstract】Objective：Chaihushugan Powder Liujunzi soup side effect of chronic hepatitis B patients. Methods：for the 60 patients with chronic hepatitis B were randomly divided into two groups: control group of 30 patients with intramuscular injection of matrine injection, 2ml / times, every other day 1, were treated with normal liver protection drugs; treatment group, 30 cases In the control group, based on the co-added services CHSGS Liujunzi soup side, 1 / day, twice taking the decoction. 180d both groups was 1 course of treatment. Before and after treatment were observed clinical symptoms and signs, liver function, HBV-DNA, HBV markers changes. Results：The total effective rate was 93.3%, 70.0% in the control group, the two groups, the difference was statistically significant (P0.05). Treatment group, HBV-DNA negative rate of 36.7% (11/30), HBeAg seroconversion rate was 23.3% (7 / 30), the control group were 13.3% (4/30) and 6.7% (2/30). There were significant differences between the two groups (P0.05). Conclusion：The combined side CHSGS Liujunzi Tang on improving clinical symptoms of chronic hepatitis B, liver function, promote HBV-DNA, HBeAg seroconversion has a good effect.