桂枝茯苓胶囊对子宫肌瘤患者血清性激素水平影响.docVIP

桂枝茯苓胶囊对子宫肌瘤患者血清性激素水平影响 　　[摘要] 目的 探讨桂枝茯苓胶囊治疗子宫肌瘤的疗效以及对子宫肌瘤患者血清性激素水平的影响机制。 方法 将入院确诊的70例子宫肌瘤患者随机分为观察组（桂枝茯苓胶囊联合西医治疗）和对照组（单纯西医治疗）各35例，比较两组治疗前后的临床疗效及血清性激素的变化情况。 结果 观察组的疗效优于对照组（P ＜ 0.01）。两组的瘤体均明显缩小，FSH、LH、E2、P均明显降低，且观察组较对照组改善明显，差异有统计学意义（P ＜ 0.05）。 结论 在西医治疗的基础上应用桂枝茯苓胶囊可显著提高临床疗效，考虑可能是通过激素水平起作用，其具体机制尚有待进一步研究。 　　[关键词] 子宫肌瘤；桂枝茯苓胶囊；血清性激素水平 　　[中图分类号] R737.33[文献标识码] B[文章编号] 1673-9701（2012）10-0080-02 　　Impact of Guizhifuling capsule on serum sex hormone levels in patients with uterine fibroids 　　YING Lijian 　　Department of Pharmacy，TCM Hospital of Ningbo City in Zhejiang Province，Ningbo 315000，China 　　[Abstract] Objective To investigate the efficacy of Guizhifuling capsule of uterine fibroids treatment, as well as uterine fibroids serum sex hormone levels in the mechanism. Methods The hospital diagnosed 70 cases of uterine fibroids were randomly divided into two groups (Western Guizhifuling capsule therapy) and control group (Western medicine alone treatment) of 35 patients were compared before and after treatment of the clinical efficacy and changes in serum sex hormone situation. Results The effective than the control group (P 0.01). Two groups of tumors were significantly reduced, FSH, LH, E2, P in observation group were significantly lower, than that in control group improved more significantly, the difference was statistically significant （P 0.05）. Conclusion In western medicine, based on the application GuizhiFuling capsule can significantly improve the clinical efficacy, consider hormone levels may play a role through its specific mechanism remains to be further studied. 　　[Key words] Uterine fibroids；Guizhifuling capsule；Serum sex hormone levels 　　子宫肌瘤是妇产科的常见病、多发病，发病率逐年升高，目前临床治疗子宫肌瘤西医主要为药物和手术治疗，但价格昂贵、副作用较大，且有停药反跳现象及复发率高等缺点[1]。近年来，中医中药治疗子宫肌瘤均取得较好疗效而逐渐受到广大患者的欢迎。中药治疗子宫肌瘤对女性正常生理功能无不良影响，且疗效明显。中医认为子宫肌瘤属于妇科疾病，主要治疗代表方药为桂枝茯苓胶囊。桂枝茯苓胶囊是古方桂枝茯苓丸的现代剂型，由桂枝茯苓丸加减而成，由桂枝、茯苓、丹皮、桃仁、芍药等组成。诸药相伍，共奏活血化瘀、祛痰利水、消症化积之功[2]。桂枝茯苓胶囊用于治疗妇科疾病如痛经、闭经、恶露不尽以及治疗盆腔炎症及包块和盆腔良性肿瘤如子宫肌瘤、子宫腺肌症、卵巢囊肿等，还用于减少药物流