氟哌噻吨美利曲辛片联合门冬胰岛素治疗糖尿病焦虑抑郁情绪障碍研究.docVIP

氟哌噻吨美利曲辛片联合门冬胰岛素治疗糖尿病焦虑抑郁情绪障碍研究 　　[摘要] 目的 探讨氟哌噻吨美利曲辛片（黛力新）联合门冬胰岛素治疗糖尿病合并焦虑抑郁情绪障碍的临床疗效。 方法 将本院近年治疗的糖尿病合并焦虑抑郁情绪障碍患者132例随机分为A、B两组，各66例，均给予门冬胰岛素降血糖等常规治疗，A组在常规治疗的基础上加用氟哌噻吨美利曲辛片，2片/d，早晨、中午各1片，比较两组治疗前后抑郁自评量表（SDS）和焦虑自评量表（SAS）的评分情况、血糖水平、血糖达标时间、胰岛素用量、不良反应。 结果 治疗后A组患者SDS、SAS评分明显低于B组（P0.05）； A组患者空腹血糖及餐后2 h血糖明显低于B组（P0.05）；A组患者血糖达标时间和胰岛素用量小于B组（P0.05）。 结论 氟哌噻吨美利曲辛片联合门冬胰岛素治疗糖尿病合并焦虑抑郁情绪障碍临床疗效较好。 　　[关键词] 2型糖尿病；焦虑；抑郁；氟哌噻吨美利曲辛 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2013）11（b）-0078-02 　　Research about flupentixol melitracen tablets plus insulin aspart in treatment of diabetes complicating with anxiety and depression disorders 　　YU Xiang-dong BAO Dai-fang WANG Juan ZHU Cui-zhen 　　Chinese Medicine Hospital of Chengde City in Hebei Province， Chengde 067000，China 　　[Abstract] Objective To investigate clinical efficacy of diabetes with anxiety and depression disorder treated with flupentixol melitracen piece （deanxit） combined insulin aspart. Methods 132 cases of diabetes mellitus complicated with anxiety and depression disorders in our hospital were randomly divided into group A and group B， each of 66 patients， and all patients were given conventional treatment such as insulin aspart. On basis of conventional treatment， group A was given deanxit， 2 tablets/d， morning， noon each one tablet. Before and after treatment， self-rating depression scale（SDS） and self-rating anxiety scale（SAS） score situation， blood sugar levels， recover time of blood glucose， insulin dosage， adverse reactions of two groups were observed and compared. Results After treatment， SDS and SAS score of patients in group A were lower than that in group B， and the difference was significant（P0.05）； Fasting blood glucose and 2 h postprandial blood glucose of group A was lower than that in group B， the difference was significant（P0.05）； blood glucose control time and insulin amount of group A was less than group B， the difference was significant（P0.05）. Conclusion Clinical efficacy of flupentixol melitracen tabl