氟尿嘧啶缓释剂局部化疗配合中晚期鼻咽癌放疗临床观察.docVIP

氟尿嘧啶缓释剂局部化疗配合中晚期鼻咽癌放疗临床观察 　　[摘要] 目的 探讨氟尿嘧啶缓释剂（5-Fu）局部化疗配合中晚期鼻咽癌患者放疗的疗效。方法 中晚期鼻咽癌患者共60例，自愿作局部化疗+放疗患者30例为A组，顺铂增敏全身化疗+放疗患者30例为B组，A组患者于放疗开始同时在瘤体内植入5-Fu，B组作顺铂增敏全身化疗+放疗，两组放疗方法及剂量相同。结果 A组与B组治疗前肿瘤体积差异无统计学意义P=0.491；治疗2周后及5周后A组肿瘤体积缩小率均大于B组，差异有统计学意义（P0.01）。结论 5-Fu在瘤体内可持久保持较高药物浓度，实现了靶点给药目的。应用于中晚期鼻咽癌患者放射治疗中，明显增强了疗效，为临床开辟了一条新的有效的治疗途径。 　　[关键词] 植入缓释制剂；肿瘤；药物治疗；放射治疗 　　[中图分类号] R735.9 [文献标识码] A [文章编号] 1674-0742（2013）07（c）-0011-03 　　Clinical Observation on the Treatment of Intermediate and Advanced Nasopharyngeal Carcinoma by Local Chemotherapy with Sustained-release 5-fluorouracil and Radiotherapy 　　HE Fucheng SHEN Kang CHEN Terui CUI Jiang CAO Jirong PANG Wei 　　Donghua Hospital Affiliated to Zhongshan University， Guangdong Province，Dongguan 523110， China 　　[Abstract] Objective Investigate the release agent fluorouracil （5-Fu） in locally advanced nasopharyngeal carcinoma chemotherapy combined with radiation therapy. Methods A total of 60 patients with nasopharyngeal carcinoma were divided into group A and group B： group A was of 30 patients who were willing to treat the cancer by local chemotherapy and radiotherapy， and at the beginning of radiotherapy， 5 - Fu was implanted into the tumour. Group B was of 30 patients who were treated by cisplatin sensitivity of chemotherapy and radiotherapy. The radiation method and dose are of the same in both groups. Results Before treatment， there was no statistically significant difference in the tumor size （P=0.491） of group A and group B； 2 weeks and 5 weeks after the treatment， the tumor shrinkage rate of group A was greater than that of group B， the difference was statistically significant （P0.001）. Conclusion Implant 5 - Fu into tumors can achieve the target for medicine purpose. It obviously enhances the curative effect when applying this method in treating intermediate and advanced nasopharyngeal carcinoma and opens up a new way of effective treatment 　　[Key words] Implant sustained-release preparations； Tumour； Medication； Radiothe