氨基酮戊酸光动力疗法与冷冻治疗尖锐湿疣合并外阴阴道念珠菌病疗效对比研究.docVIP

氨基酮戊酸光动力疗法与冷冻治疗尖锐湿疣合并外阴阴道念珠菌病疗效对比研究 　　【摘要】目的：分析氨基酮戊酸光动力联合抗真菌治疗尖锐湿疣合并外阴阴道念珠菌病临床疗效及安全性。方法：选择在本院接受治疗的尖锐湿疣合并外阴道念珠菌病患者86例为研究对象，分别接受冷冻联合抗真菌治疗及氨基酮戊酸光动力联合抗真菌治疗，比较两组治疗效果及临床安全性差异。结果：观察组患者尖锐湿疣治疗有效率、真菌感染治疗有效率明显高于对照组[93.8% VS 76.08%，95.65% VS 80.43%]（χ2=3.842、3.748，P=0.028、0.0320.05）；观察组不良反应发生率、尖锐湿疣复发率、外阴阴道念珠菌病复发率均明显低于对照组[4.34% VS 19.56%、9.38% VS23.81%、5.88% VS 17.39%]（χ2=5.324、5.854、4.356，P=0.022、0.018、0.0360.05）。结论：氨基酮戊酸光动力联合抗真菌治疗可以显著提高尖锐湿疣合并外阴阴道念珠菌病患者的治疗效果，具有良好的治疗安全性。 　　【关键词】尖锐湿疣；外阴阴道念珠菌病；氨基酮戊酸光动力；抗真菌 　　A comparison of the curative effect between aminolevulinic acid-photodynamic therapy and frozen therapy in treating patients with condyloma acuminatum and vulvovaginal candidiasisSHENG Hao1， QI Xiping2. 1. Department of Dermatology STD， Puren Hospital of Wuhan， Wuhan 430080， China； 2. Department of Dermatology， Wuhan First Peoples Hospital， Wuhan 430022， China 　　【Abstract】Objectives： To analyze the clinical curative effect and safety of aminolevulinic acid-photodynamic combined with anti-fungal therapy in treating patients with condyloma acuminatum and vulvovaginal candidiasis. Method： 86 patients with condyloma acuminatum and vulvovaginal candidiasis were chosen as the research object， where control group were treated with frozen and antifungal therapy， and observation group were treated with aminolevulinic acid-photodynamic combined with antifungal therapy. Treatment effect and differences in clinical safety of the 2 groups were compared. Results： The treatment effectiveness of condyloma acuminatum and fungal infection of the observation group was significantly higher than those of the control group [93.8% VS 76.08%， 95.65% VS 80.43%] （χ2=3.842/3.748， P=0.028， 0.0320.05）； the incidence of side effects and the recurrence rates of verruca acuminate and fungal infection were significantly lower than the control group [4.34% VS 19.56%， 9.38% VS23.81%， 5.88% VS 17.39%] （χ2=5.324， 5.854， 4.356， P=0.022， 0.018， 0.0360.05）. Conclusion： The aminolevulinic acid-photodynamic comb