氨基葡萄糖胶囊联合玻璃酸钠治疗膝骨性关节炎疗效及对炎症因子水平影响.docVIP

氨基葡萄糖胶囊联合玻璃酸钠治疗膝骨性关节炎疗效及对炎症因子水平影响 　　[摘要] 目的 探讨氨基葡萄糖胶囊联合玻璃酸钠治疗膝骨性关节炎的疗效及对炎症因子水平的影响。 方法 70例膝骨性关节炎患者随机分为观察组和对照组。两组均予以玻璃酸钠针25 mg关节腔内注射，1次/周。观察组在对照组基础上加用盐酸氨基葡萄糖胶囊，2粒/次，3次/d，口服。两组病程均6周。分别于治疗前后观察血清超敏C反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）指标的变化，并比较其临床效果及不良反应。 结果 治疗6周后，两组血清hs-CRP和TNF-α水平明显下降（P0.05）。 结论 氨基葡萄糖胶囊联合玻璃酸钠治疗膝骨性关节炎的疗效优于单纯的玻璃酸钠治疗，具有较好的安全性，其?l病机制可能与其能下调血清hs-CRP和TNF-α指标、控制其炎症反应密切相关。 　　[关键词] 骨性关节炎；膝；玻璃酸钠；氨基葡萄糖胶囊；炎症因子 　　[中图分类号] R684.3 [文献标识码] A [文章编号] 1673-9701（2018）07-0016-04 　　[Abstract] Objective To investigate the therapeutic effect of glucosamine capsule combined with sodium hyaluronate in the treatment of knee osteoarthritis and its effect on the level of inflammatory cytokines. Methods 70 knee osteoarthritis patients were randomly divided into observation group and control group. Both groups were given intra-articular injection of 25 mg sodium hyaluronate needle， once a week. The observation group was further orally given two capsules of glucosamine hydrochloride capsules once， three times a day. The duration of both groups was 6 weeks. The changes of serum hs-CRP and TNF-α were observed before and after treatment， and their clinical effects and adverse reactions were compared. Results After 6 weeks of treatment， the serum levels of hs-CRP and TNF-α in both groups were significantly decreased（P0.05）. Conclusion The therapeutic effect of glucosamine capsules combined with sodium hyaluronate in the treatment of knee osteoarthritis is better than that of sodium hyaluronate alone. It has a good safety. Its pathogenesis may be closely related to its ability to down-regulate serum hs-CRP and TNF-α， and control their inflammatory response. 　　[Key words] Osteoarthritis；Knee；Sodium hyaluronate；Glucosamine capsule；Inflammatory factors 　　骨性关节炎（osteoarthritis，OA）是骨关节退行性疾病，好发于老年人，其病情发展较慢，引起关节软骨变性、磨损及骨赘形成，严重时导致关节功能丧失[1，2]。膝骨性关节炎的发病机制至今不明，研究已证实炎症因子网络紊乱在其发病过程中的作用受到临床重视[3]。玻璃酸钠，又称透明质酸，是一种酸性黏多糖，是组成关节滑液和软骨的主要有效成分，在关节腔内起润滑、营养和保护软骨作用。关节腔内注射玻璃酸钠治疗膝骨性关节炎是目前临床常用的治疗手段，具有较好的临床效果，但部分患者疗效欠理想[4-