氨氯地平联合阿托伐他汀钙治疗高血压合并冠心病疗效观察.docVIP

氨氯地平联合阿托伐他汀钙治疗高血压合并冠心病疗效观察 　　【摘要】 目的 探究氨氯地平?合阿托伐他汀钙片治疗高血压合并冠心病的疗效。方法 108例高血压合并冠心病患者， 按照随机原则分为对照组与观察组， 各54例。对照组采用阿托伐他汀钙胶囊进行治疗， 观察组采用氨氯地平联合阿托伐他汀钙片进行治疗。观察并分析两组患者治疗前后的舒张压和收缩压以及心功能指标。结果 治疗前两组舒张压、收缩压、每搏输出量（SV）、射血分数（EF）比较差异均无统计学意义（P0.05）。治疗后两组舒张压、收缩压均低于本组治疗前， 差异均具有统计学意义（P0.05）；治疗后观察组舒张压、收缩压分别为（91.20±9.52）、（116.24±9.52）mm Hg（1 mm Hg=0.133 kPa）均低于对照组的（109.57±12.41）、（133.46±12.74）mm Hg， 差异均具有统计学意义（P0.05）。治疗后两组SV、EF均高于本组治疗前， 差异均具有统计学意义（P0.05）；治疗后观察组SV、EF分别为（57.14±11.27）ml、 　　（66.95±1.79）%， 均高于对照组的（42.95±10.74）ml、（51.63±1.55）%， 差异均具有统计学意义（P0.05）。 　　结论 氨氯地平联合阿托伐他汀钙片有利于降低高血压合并冠心病患者的血压， 改善心脏功能， 效果较为显著， 应予以推广使用。 　　【关键词】 氨氯地平；阿托伐他汀；高血压；冠心病；疗效 　　DOI：10.14163/j.cnki.11-5547/r.2017.36.056 　　Observation on efficacy of amlodipine combined with atorvastatin calcium in the treatment of hypertension complicated with coronary heart disease HE Hong， ZHONG Wei-zhang， LEI Yan. Department of Pharmacy， Guangdong Gaozhou People’s Hospital， Gaozhou 525200， China 　　【Abstract】 Objective To investigate the efficacy of amlodipine combined with atorvastatin calcium in the treatment of hypertension complicated with coronary heart disease. Methods A total of 108 patients with hypertension complicated with coronary heart disease as study subjects were randomly divided into control group and observation group， with 54 cases in each group. The control group was treated with atorvastatin calcium capsule， and the observation group was treated with amlodipine combined with atorvastatin calcium tablets. Observation and analysis were made on diastolic blood pressure and systolic blood pressure， and cardiac function indexes before and after treatment in two groups. Results Before treatment， both groups had no statistically significant difference in diastolic blood pressure， systolic blood pressure， stroke volume （SV）， ejection fraction （EF） （P0.05）. After treatment， both groups had lower diastolic blood pressure and systolic blood pressure than before treatment， and their difference was statistically signi