氨氯地平联合吲达帕胺治疗舒张压升高为主原发性高血压62例疗效观察.docVIP

氨氯地平联合吲达帕胺治疗舒张压升高为主原发性高血压62例疗效观察 　　[摘要] 目的 评价氨氯地平联合吲达帕胺治疗舒张压升高为主的原发性高血压的临床疗效。 方法 124例舒张压升高为主的原发性高血压患者随机分为两组：治疗组62例，给予氨氯地平片（5 mg，1次/d）和吲达帕胺片（2.5 mg，1次/d）；对照组62例，给予硝苯地平缓释片（20 mg，2次/d）；每周测量坐位血压1次，随访8周，观察两组血压及血生化指标变化，分析两组患者数据得出结论。 结果 随访8周，两组患者舒张压均下降，但对照组舒张压下降不满意，治疗组患者血压控制水平均达标，达到正常血压值以下，治疗组疗效明显优于对照组，两组间差异有统计学意义（P0.05），两组患者的肝功能、肾功能、血脂、血糖、电解质、血尿酸等指标变化无统计学意义。结论 氨氯地平联合吲达帕胺治疗舒张压升高为主的原发性高血压疗效显著，安全性好，二者合用???一种合理可靠的治疗舒张期高血压方案。 　　[关键词] 氨氯地平；吲达帕胺；舒张压升高；联合治疗 　　[中图分类号] R544.1 [文献标识码] B [文章编号] 1673-9701（2015）12-0078-03 　　Effect of amlodipine combined with indapamide in treatment of diastolic blood pressure as the main primary hypertension of 62 cases 　　SHANG Shiguo GUO Qin 　　Department of Internal Medicine， Shiyan Railway Hospital in Hubei Province，Shiyan 442716，China 　　[Abstract] Objective To evaluate the clinical curative effect of amlodipine combined with indapamide treating diastolic blood pressure as the main primary hypertension. Methods All 124 sence diastolic blood pressure primarily in patients with essential hypertension were divied randomly into two groups.The patients in treatment group （n=62）took amlodipine tablets（5 mg，1 time/d） and indapamide tablets（2.5 mg，1 time/d）；the patients in control group （n=62）took extended release nifedipine tablets （20 mg，2 times/d）by mouth；sitting blood pressure was taken 1 times a week， followed up for 8 weeks， the changes of blood pressure and blood biochemical indexes of two groups were observed，the data was concluded through the analysis of the two groups of patients. Results Followed up for 8 weeks， two groups of patients with diastolic blood pressure decreased，but the control group diastolic pressure drops was not satisfied，the treatment group patients level of blood pressure control were standard，achieve normal blood pressure value of the following，the efficacy of the treatment group was significantly better than the control group， the difference was statistically significant between the two groups （P0.05）， the changes of li