植物雌激素在防治心肌缺血再灌注损伤应用前景.docVIP

植物雌激素在防治心肌缺血再灌注损伤应用前景 　　[摘要]心肌缺血再灌注损伤是心血管疾病领域研究的热点问题之一，目前临床上尚缺乏有效的防治手段。临床研究发现冠心病的绝经前女性患者要明显低于男性患者，说明雌激素在其发生发展过程中具有一定的作用，使雌激素替代疗法逐渐成为新的防治研究热点。大量植物雌激素应用于心血管疾病的预防治疗研究，以期消除合成类雌激素在治疗中副作用。该文总结了雌激素受体在心肌缺血再灌注损伤中的作用，雌激素替代疗法的应用及局限性，以及植物雌激素在其防治过程中的应用前景，以期为开发安全、有效的新型药物提供思路和参考。 　　[关键词]心肌缺血再灌注损伤; 植物雌激素 　　Phytoestrogens in application prospect of treatment of 　　myocardial ischemia/reperfusion injury 　　LI Guang1，2， XING Xiao-yan1*， ZHANG Mei-shuang1， SHI Jin-jin1， DENG Xue-hong1， SUN Gui-bo1， SUN Xiao-bo1* 　　（1.The Institute of Medicinal Plant Development， Chinese Academy of Medical Sciences， Beijing 100093， China; 　　2.Yunnan Branch， Institute of Medicinal Plant Development， Chinese Academy of Medical Sciences， Jinghong 666100， China） 　　[Abstract]Reperfusion is the most effective treatment for acute myocardial infarction， markedly reducing mortality and morbidity. Reperfusion however induces necrotic and apoptotic damages to cardiomyocytes， that were viable prior to reperfusion， a process called myocardial ischemia/reperfusion injury（MI/RI）. Over the past 30 years， hundreds of experimental interventions （both pharmacologic and nonpharmacologic） have been reported to protect the ischemic myocardium in experimental animals; however， with the exception of early reperfusion， none has been translated into clinical practice. The population-based survey assessed men have about twice the total incidence of morbidity and mortality of women， and the sex gap in morbidity tends to diminish after age 45 years. So hormone replacement therapy （HRT） is given to treat the MI/RI， and lots of studies shows that the side effect is greater for estrogen， compared with phyestrogen. In this article， we review the important pathogenesis of myocardial ischemia reperfusion injury， the prevention and limitations of HRT. And we highlight the mechanism of phyestrogens treatment the MI/RI in experiment. The aim is to provide the theoretically new way of develop the safe and effective products for the re