瑞舒伐他汀改善动脉硬化性脑梗死患者血脂与神经功能临床研究.docVIP

瑞舒伐他汀改善动脉硬化性脑梗死患者血脂与神经功能临床研究 　　【摘要】 目的：研究瑞舒伐他汀对改善动脉硬化性脑梗死患者的血脂和神经功能的作用。方法：选取2013-2015年笔者所在医院收治的94例动脉硬化性脑梗死患者，随机分为试验组和对照组，各47例，对照组仅行脑梗死常规治疗，试验组行常规治疗后加用瑞舒伐他汀，连用1个月后观察比较两组患者的血脂水平和神经功能的变化。结果：治疗1个月后，试验组的血脂水平改善状况较对照组更佳，差异有统计学意义（P0.05）；且试验组的神经功能评估状况较对照组更佳，差异有统计学意义（P0.05）。结论：瑞舒伐他汀对于改善动脉硬化性脑梗死患者的血脂有极佳的效果，且能够有效改善患者的神经功能，值得临床推广使用。 　　【关键词】 瑞舒伐他汀； 动脉性脑梗死； 血脂； 神经功能 　　中图分类号 R743.33 文献标识码 B 文章编号 1674-6805（2016）22-0046-03 　　【Abstract】 Objective：To study the effect of rosuvastatin on blood lipid and nerve function in patients with arteriosclerosis cerebral infarction.Method：94 patients with arteriosclerosis cerebral infarction were selected in our hospital from 2013 to 2015，they were randomly divided into the experimental group and the control group， 47 cases in each group，the control group was only given with routine therapy for cerebral infarction，the experimental group was received rosuvastatin on the basis of routine treatment，the blood lipid level and the changes of nerve function in the two groups were observed and compared after one month.Result：After 1 month of treatment，the improvement of blood lipid level in experimental group was better than that in control group，the difference was statistically significant（P0.05）.The neurological function of the test group was better than the control group，the difference was statistically significant（P0.05）.Conclusion：The effect of rosuvastatin on blood lipids in patients with arteriosclerosis cerebral infarction is excellent，and it can effectively improve the nerve function of patients，which is worthy of clinical application. 　　【Key words】 Rosuvastatin； Arterial cerebral infarction； Blood lipid； Nerve function 　　First-author’s address：The First Affiliated Hospital，Sun Yat-sen University，Guangzhou 510000，China 　　doi：10.14033/j.cnki.cfmr.2016.22.023 　　脑梗死是危害中老年人身体健康的重要疾病之一[1]，其中，脑血栓形成是脑梗死的常见类型，动脉粥样硬化是其最根本的原因，主要发生在管径500 μm以上的动脉，导致血栓形成和血管管腔狭窄，从而引起脑部局部血流供应中断，神经细胞因缺血缺氧而坏死或凋亡，轻者导致患者失明、失语、偏瘫等，重者危及患者生命，需紧急抢救[2]。临床上针对动脉硬化性脑梗死的病因治疗多以降血压、溶栓