生血宁片辅助放化疗对肺癌术后患者T淋巴细胞亚群及IL―23IL―17水平影响.docVIP

生血宁片辅助放化疗对肺癌术后患者T淋巴细胞亚群及IL―23IL―17水平影响 　　[摘要] 目的 观察生血宁片辅助放化疗对肺癌术后患者T淋巴细胞亚群及白介素-23（IL-23）、白介素-17（IL-17）水平的影响。 方法 选取2015年10月～2017年1月承德医学院附属医院收治的肺癌术后患者92例作为研究对象，按照随机数字表法将其分为观察组和对照组，每组各46例。对照组给予同步放化疗治疗，观察组在对照?M的基础上联合生血宁片治疗。治疗后，评价两组临床疗效，观察外周血象、免疫功能、IL-23、IL-17水平以及不良反应发生率。 结果 观察组总有效率（73.91%）显著高于对照组（52.17%），差异有统计学意义（P 0.05）。治疗后观察组CD3+、CD4+、CD8+水平与治疗前比较差异无统计学意义（P 0.05），CD4+/CD8+水平显著低于治疗前（P 0.05），观察组胃肠道反应、骨髓抑制发生率显著低于对照组（P 0.05）。 结论 生血宁片辅助放化疗能够有效改善患者外周血象和T淋巴细胞亚群水平，降低IL-23、IL-17水平和不良反应发生率，提高临床疗效。 　　[关键词] 生血宁片；放化疗；肺癌；白介素-23；临床疗效 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-7210（2018）01（b）-0087-05 　　[Abstract] Objective To observe the influence of Shengxuening Tablets adjuvant chemotherapy on T lymphocyte subsets and interleukin-23 （IL-23） and interleukin-17 （IL-17） levels of postoperative patients with lung cancer. Methods Ninety-two cases of postoperative patients with lung cancer treated in Affiliated Hospital of Chengde Medical University from October 2015 to January 2017 were selected as the study objects， and they were divided into observation group and control group according to random number table method， with 46 cases in each group. The control group was given concurrent chemoradiotherapy， and the observation group was added with Shengxuening Tablets on the basis of the control group. After treatment， the clinical efficacy was evaluated， and the peripheral blood， immune function， levels of IL-23 and IL-17， and the incidence of adverse reactions were observed in the two groups. Results The total effective rate of the observation group （73.91%） was significantly higher than that of the control group （52.17%） （P 0.05）. There were no significant differences of the levels of CD3+， CD4+ and CD8+ in the observation group before and after treatment （P 0.05）， while the level of CD4+/CD8+ in the observation group after treatment was significantly lower than that before treatment （P 0.05）. The incidence of gastrointestinal reactions and myelosuppression in the observation gr