甘精胰岛素联合瑞格列奈治疗老年患者糖尿病肾病疗效观察.docVIP

甘精胰岛素联合瑞格列奈治疗老年患者糖尿病肾病疗效观察 　　【摘要】 目的：评估甘精胰岛素联合瑞格列奈治疗老年患者糖尿病肾病的临床疗效。方法：选择2012年 　　1月-2014年11月本院收治的2型糖尿病合并早期肾病的60例老年患者，按照随机数字表法将其分为试验组和对照组，每组30例。试验组给予甘精胰岛素联合瑞格列奈治疗，对照组给予诺和灵30R治疗，观察比较两组患者的临床疗效、治疗前后血糖控制情况、肾功能水平的变化情况以及低血糖事件发生率。结果：经过12周对应治疗后，试验组的治疗总有效率93.3%明显高于对照组的73.3%，比较差异有统计学意义（ 字2=4.3200，P=0.0377）。试验组患者治疗后的空腹血糖、餐后2 h血糖及糖化血红蛋白水平均明显优于对照组，尿素氮、血清肌酐、肾小球滤过率、尿白蛋白排泄率均明显低于对照组，且低血糖事件发生率明显低于对照组，差异均有统计学意义（P0.05）。结论：甘精胰岛素联合瑞格列奈治疗老年2型糖尿病肾病的临床效果良好，能够有效减少并发症的发生，降低低血糖事件发生率，值得临床推广应用。 　　【关键词】 甘精胰岛素； 瑞格列奈； 糖尿病肾病 　　【Abstract】 Objective：To evaluate the clinical efficacy of Insulin glargine combined with Repaglinide in the treatment of elderly type 2 diabetic nephropathy.Method：60 elderly patients with type 2 diabetes mellitus and early nephropathy admitted to our hospital from January 2012 to November 2014 were selected，and they were divided into the experimental group and the control group according to the random number table method，30 cases in each group.The experimental group was given Insulin glargine combined with Repaglinide for treatment，the control group was given Novolin 30R for treatment.The clinical curative effect，the changes of blood glucose and kidney function before and after treatment，incidence of hypoglycemic events between the two groups were observed and compared.Result：After 12 weeks of treatment，the total effective rate of the experimental group was 93.3%，which was significantly higher than 73.3% of the control group，the difference was statistically significant（ 字2=4.3200，P=0.0377）.The fasting blood-glucose，postprandial 2 h blood glucose glycosylated hemoglobin level of the experimental group after treatment were significantly better than those of the control group，the usea nitrogen，serum creatinine，glomerular filtration rate and urinary albumin excretion rate were significantly lower than those of the control group，the incidence of hypoglycemic events was significantly lower than the control group，the differences were statistically significant（P0.05）.Conclusion：Th