生长抑素和蛇毒血凝酶联合奥美拉唑治疗急性上消化道出血可行性分析.docVIP

生长抑素和蛇毒血凝酶联合奥美拉唑治疗急性上消化道出血可行性分析 　　[摘要]目的 探讨奥美拉唑联合生长抑素和蛇毒血凝酶治疗急性上消化道出血的临床效果。方法 选择2013年3月～2016年3月在我院治疗的急性上消化道出血患者82例，随机分为实验组和对照组，各41例，实验组采用奥美拉唑联合生长抑素和蛇毒血凝酶治疗，对照组仅采用奥美拉唑治疗，比较两组止血效果、止血时间、不良反应发生率及患者和家属满意度。结果 实验组止血有效率及患者和家属满意率均显著高于对照组（P0.05），实验组止血时间显著短于对照组（P0.05），且不良反应发生率低于对照组，差异有统计学意义（P0.05）。结论 奥美拉唑联合生长抑素和蛇毒血凝酶治疗急性上消化道出血的效果更确切，可快速止血，稳定生命体征，显著缩短止血时间，不良反应少，安全性好，患者和家属满意度良好，值得临床推广。 　　[关键词]生长抑素；蛇毒血凝酶；奥美拉唑；急性上消化道出血 　　[中图分类号] R573.2 [文献标识码] A [文章编号] 1674-4721（2017）02（b）-0134-03 　　[Abstract]Objective To explore the effect of Omeprazole combined with somatostatin and snake venom blood clotting enzyme in the treatment of acute upper gastrointestinal bleeding.Methods From March 2013 to March 2016，82 acute upper gastrointestinal bleeding patients were randomly divided into experimental group and control group，41 cases in each groups.The experimental group was adopted Omeprazole combined with somatostatin and snake venom blood clotting enzyme，the control group only was adopted Omeprazole.The hemostatic effect，hemostatic time，the incidence of adverse reactionsand patients′satisfaction of two groups were compared Results The hemostatic effect and the patients′ satisfaction were significantly higher than those of control group （P0.05），the hemostatic time was significantly shorter than the control group （P0.05），the incidence of adverse reactions was lower than that of control group，that of difference was significant（P0.05）.Conclusion The experimental group has exact curative effect，shorter hemostatic time and less adverse reactions.The patients are almost satisfied with it，which is worth to promoting. 　　[Key words]Somatostatin；Snake venom blood clotting enzyme；Omeprazole；Acute upper gastrointestinal bleeding 　　急性上消化道出血是指屈氏韧带以上消化道的急性出血，常见病因有消化性溃疡、急性胃黏膜损伤、食管胃底静脉曲张和胃癌等，近年来发病率逐年上升[1]。该病起病急、病程较短，患者主要表现为呕血和黑便，常伴有血容量减少和贫血。当出血量较多时，会引起周围循环衰竭，产生一系列意识模糊、皮温降低、尿量减少、黏膜苍白、四肢厥冷、冷汗淋漓、体表静脉塌陷、血压下降等症状体征，对生命造成威胁[2]。现临床上常使用药物、三腔二囊管、内镜下治疗等方式止血，其中止血药物多用质子泵抑制剂和H2受体拮抗剂，但对部分患者效果欠佳[3]。据研究显示，使用生长抑素和蛇毒血凝酶治疗其他出