神经内分泌指标对EV71感染手足口病诊断价值.docVIP

神经内分泌指标对EV71感染手足口病诊断价值 　　[摘要] 目的 探讨神经内分泌以及免疫学部分指标在EV71感染所致手足口病患儿病情评估中的价值。 方法 将我院收治的210例EV71感染所致小儿手足口病分为普通患儿112例（A组）、重症患儿57例（B组）和危重型患儿41例（C组）；另选择同期在我院检查的健康患儿80例作为对照组；分别检测各组患儿皮质醇（COR）、β-内啡肽（β-EP）、免疫球蛋白、淋巴细胞亚群、B淋巴细胞、自然杀伤细胞（NK细胞）、白细胞介素-13（IL-13）、干扰素-γ（IFN-γ）水平。 结果 A、B、C三组COR、β-EP、IL-13、IFN-γ、NK细胞（CD19+）水平显著高于对照组（P0.05）；B组、C组IgG、IgA、IgM水平显著高于对照组（P0.05）；随着病情的加重，各指标水平逐渐升高。B组、C组CD3+、CD4+、CD8+等T细胞亚群及B淋巴细胞（CD16+ CD56+）水平显著低于对照组，随着疾病的加重，CD3+、CD4+、CD8+、CD16+ CD56+显著降低，差异有统计学意义（P0.05）。 结论 EV71感染所致手足口病伴有细胞免疫、体液免疫等免疫功能紊乱，并与疾病进展密切相关；对患儿进行免疫指标和神经内分泌指标监测，有助于评估患儿的病情。 　　[关键词] 神经内分泌指标；免疫学指标；肠道病毒71型；手足口病 　　[中图分类号] R725.1 [文献标识码] A [文章编号] 1673-9701（2015）09-0016-03 　　Value of neuroendocrine indices in the diagnosis of hand-foot-mouth disease infected by EV71 　　WANG Yudan1 ZHAO Shiyong2 WU Ye1 　　1.Department of Pediatrics， Huzhou Central Hospital in Zhejiang Province， Huzhou 313000，China；2.Department of Pediatrics， the Sixth Peoples Hospital of Hangzhou City， Hangzhou 310023，China 　　[Abstract] Objective To explore the value of neuroendocrine indices and some immune indices in the assessment of conditions for children patients with hand-foot-mouth disease infected by EV71. Methods All 210 children patients with hand-food-mouth disease infected by EV71 who were admitted to our hospital were divided into three groups， 112 normal patients （group A）， 57 severe patients （group B） and 41 critical patients （group C）； 80 healthy children who received examination in our hospital during the same period of time were selected as control group； levels of COR， β-EP， immune globulin， lymphocyte subpopulation， B lymphocytes， natural killer cells （NK cells）， IL-13， and IFN-γ were tested in each group. Results Levels of COR， β-EP， IL-13， IFN-γ and NK cells（CD19+） in group A， B and C were significantly higher than those in control group（P 　　[Key words] Neuroendocrine indices； Immunological indices； Enterovirus 71； Hand-foot-mouth disease 　　由肠道病毒71型（EV71）感染所致小儿手足口病临床上较为常见，其临床表现也呈多样性[1]。研究显示[2]EV71病毒存在