神经节苷脂和鼠神经生长因子联合治疗新生儿缺氧缺血性脑病可行性研究.docVIP

神经节苷脂和鼠神经生长因子联合治疗新生儿缺氧缺血性脑病可行性研究 　　【摘要】 目的 研究新生儿缺氧缺血性脑病患儿使用神经节苷脂联合鼠神经生长因子治疗的临床效果。方法 60例新生儿缺氧缺血性脑病患儿， 按照随机数字表法分为对照组和观察组， 各30例。对照组患儿采用常规治疗， 观察组患儿在常规治疗基础上给予神经节苷脂联合鼠神经生长因子治疗。治疗后， 比较两组患儿新生儿神经行为评分（NBNA）、智力发育指数（MDI）、心理运动发育指数（PDI）、临床症状改善总有效率以及血清炎性因子水平。结果 观察组患儿临床症状改善总有效率为90.00%， 高于对照组的66.67%， 差异具有统计学意义（P0.05）。观察组患儿NBNA为（36.21±3.12）分、MDI为（91.24±3.35）分、PDI为（92.84±3.82）分， 明显优于对照组的（32.21±3.24）、（82.43±3.46）、（82.54±3.74）分， 差异具有统计学意义（P0.05）。治疗后， 两组患儿血???炎性因子水平较治疗前均明显降低， 且观察组降低程度明显优于对照组， 差异具有统计学意义（P0.05）。结论 神经节苷脂联合鼠神经生长因子治疗可提高患儿治疗效果， 患儿脑损伤恢复程度很好， 值得在临床中推广应用。 　　【关键词】 神经节苷脂；鼠神经生长因子；早期干预；新生儿缺氧缺血性脑病 　　DOI：10.14163/j.cnki.11-5547/r.2016.35.005 　　【Abstract】 Objective To research clinical effect by gangliosides combined with mouse nerve growth factor in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods A total of 60 newborn with neonatal hypoxic-ischemic encephalopathy were divided by random number table into control group and observation group， with 30 cases in each group. The control group received conventional therapy， and the observation group received additional gangliosides combined with mouse nerve growth factor for treatment. After treatment， comparison was made on neonatal behavioral neurological assessment （NBNA）， mental development index （MDI）， psychomotive development index （PDI）， total effective rate of clinical symptom improvement and serum inflammatory factor levels between the two groups. Results The observation group had total effective rate of clinical symptom improvement as 90.00%， which was higher than 66.67% in the control group， and the difference had statistical significance （P0.05）. The observation group had NBNA as （36.21±3.12） points， MDI as （91.24±3.35） points and PDI as （92.84±3.82） points， which were all better than （32.21±3.24）， （82.43±3.46） and （82.54±3.74） points in the control group. Their difference had statistical significance （P0.05）. After treatment， both groups had obviously lower serum inflammatory factor levels than those before