米索前列醇不同给药途径在终止早期妊娠中临床研究.docVIP

米索前列醇不同给药途径在终止早期妊娠中临床研究 　　摘要：目的：探讨米索前列醇不同给药方式对终止早期妊娠效果的影响及安全性。 　　方法：选取符合标准的早期妊娠者200例，随机分为观察组和对照组各100例。两组患者米非司酮片给药方式相同，在此基础上对照组口服米索前列醇片600μg，必要时加用400μg，观察组将600μg米索前列醇置入阴道穹窿，比较二者流产效果。 　　结果：观察组患者宫缩发动时间、孕囊排出时间、阴道出血量及阴道流血持续时间均优于对照组，差异有统计学意义（P0.05）。观察组患者完全流产95例、不全流产4例和流产失败1例；对照组患者完全流产80例、不全流产15例和流产失败5例；观察组患者流产成功率明显高于对照组，差异有统计学意义（P0.05）。观察组患者不良反应发生率24.00%，明显低于对照组的56.00%，差异有统计学意义（P0.05）。 　　结论：米索前列醇阴道穹窿给药后宫缩发动及孕囊排出时间缩短，可以提高药物流产成功率，阴道出血量少，减少药物不良反应，值得临床推广应用。 　　关键词：早期妊娠 药物流产 米索前列醇 给药途径 　　Doi：10.3969/j.issn.1671-8801.2014.06.044 　　Abstract：Objective： To investigate the safety and effects of misoprostol administrated through different routes in termination of early pregnancy. 　　Methods：200 eligible patients with early pregnancy were selected and randomly divided into observation group and control group，100 patients each group.The patients of both groups were given with mifepristone tablets administrated through the same route，and the control group additionally orally took 600 μg，plus another 400 μg when necessary，of misoprostol tablets，while the observation group additionally placed 600 μg of misoprostol in the fundus of vagina，the miscarriage effects were compared between the two groups. 　　Result：The uterine contraction onset time，gestational sac efflux time，vaginal hemorrhage volume and vaginal hemorrhage duration in the patients of the observation group were all better than those of the control group，and the differences were statistically significant （P0.05）.Of the observation group，95 patients got complete abortion，4 got incomplete abortion，and 1 got no abortion； of the control group，80 patients got complete abortion，15 got incomplete abortion and 5 got no abortion； the abortion achievement ratio in the patients of the observation group was significantly higher than that of the control group，and the difference was statistically significant （P0.05）.The incidence of adverse reaction in the patients of the observation group was 24.00%，significantly lower than that of t