米力农对慢性充血性心力衰竭患者B型脑钠素影响.docVIP

米力农对慢性充血性心力衰竭患者B型脑钠素影响 　　[摘要] 目的 比较米力农与西地兰对慢性充血性心力衰竭患者B型脑钠素（BNP）的影响，探讨米力农在心力衰竭患者治疗中的作用。 方法 选择2011年9月～2014年12月原发性高血压2～3级、冠心病（缺血性心肌病型）疾病导致的慢性充血性心力衰竭患者200例，EF值20%～40%， BNP 200～871 pg/mL，心功能3级。全部患者随机分为两组，记录未进行任何治疗前患者血浆B型脑钠素、血钾、血肌酐数值及在接受心力衰竭常规治疗基础上分别接受米力农10 mg静滴3 d（A组）、西地兰0.2 mg静推3 d（B组）后患者的血浆各项数值。 结果 A组血浆B型脑钠素下降程度、EF值升高、心功能改善程度均明显高于B组（P0.05）。 结论 米力农及西地兰在短期内对于慢性充血性心力衰竭患者的BNP下降均有一定影响。结合临床症状、EF值等数据，在慢性心力衰竭短期治疗内，推荐米力农短期应用。 　　[关键词] 心力衰竭；米力农；B型脑钠素 　　[中图分类号] R541.6 [文献标识码] B [文章编号] 1673-9701（2015）23-0098-03 　　The impact on BNP of milrinone injection in treatment of chronic congestive heart failure 　　RAN Chongyun 　　Department of Cardiology， Jiangkou County Peoples Hospital in Guizhou Province， Jiangkou 554400， China 　　[Abstract] Objective To compare the impact on BNP of milrinone injection and cedilanide in treatment of chronic congestive heart failure， in order to investigate the status of milrinone injection in patients with heart failure therapy. Methods All 200 patients with chronic congestive heart failure from September 2011 to December 2014 were divided into two groups randomly，（EF values between 20%-40%， BNP at 200-871 pg/mL， heart function was three grade）. The BNP， serum potassium， serum creatinine values were recorded before treatment， and the indicators of conventional therapy for heart failure were treated after milrinone onintravenous infusion of 10 mg for 3 days（group A）， cedilanid 0.2 mg bolus for 3 days（group B） were compared. Results The decreasing rate of BNP， increasing of EF value and heart function improvement of group A were significantly higher than group B（P0.05）. Conclusion Milrinone injection and cedilanide in the short term for chronic congestive heart failure patients have good effect， and can significantly decrease BNP. We recommend short-term use of milrinone injection in the treatment of chronic heart failure. 　　[Key words] Heart failure； Milrinone injection； BNP 　　随着高血压、冠心病、糖尿病发病率的不断增加及老龄人口数量的不断攀升，慢性充血性心力衰竭随着发病率的逐年增高，越来越受到医学界的重视，其病因及代偿