米力农联合参麦注射液对缺血性心肌病患者心功能指标影响.docVIP

米力农联合参麦注射液对缺血性心肌病患者心功能指标影响 　　浙江省乐清市人民医院，浙江乐清 325600 　　[摘要] 目的 观察米力农联合参麦注射液对缺血性心肌病患者心功能指标的影响。 方法 选取缺血性心肌病患者160例，随机分为常规组和观察组，每组各80例，常规组常规给予血管扩张剂、利尿剂、血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂、β受体阻滞剂、洋地黄等药物，观察组在常规组治疗基础上加用米力农和参麦注射液，分别治疗7 d和14 d，观察两组治疗前及治疗后2周的临床疗效、血浆N端脑钠肽前体（NT-proBNP）水平、左室射血分数（LVEF）和6 min步行距离变化。 结果 治疗2周后，观察组总有效率明显优于常规组，观察组血浆NT-proBNP水平较常规组下降更为明显，观察组心脏超声LVEF值及6 min步行距离较常规组增加更为显著，两组比较差异有统计学意义（P 0.05）。 结论 米力农联合参麦注射液可明显改善缺血性心肌病患者各项心功能指标，短期疗效显著，且无明显不良反应。 　　[关键词] 缺血性心肌病；米力农；参麦注射液；心功能指标 　　[中图分类号] R542.22 [文献标识码] A [文章编号] 1673-7210（2014）03（a）-0069-03 　　Effect of Milrinone combined with Shenmai Injection on cardiac function indexes in patients with ischemic cardiomyopathy 　　LIU Lidan ZHI Xiaoyang XU Weiying GE Ruituo WU Xinhu LIN Xuefeng 　　Yueqing Peoples Hospital， Zhejiang Province， Yueqing 325600， China 　　[Abstract] Objective To observe the effect of Shenmai Injection combined with Milrinone on cardiac function indexes in patients with ischemic cardiomyopathy. Methods 160 cases of patients with ischemic cardiomyopathy were randomly divided into conventional group （n = 80） and observation group （n = 80）. The conventional group was treated with conventional drugs such as vasodilator， diuretics， ACEI/ARB， beta blockers， digitalis drugs， and the observation group was given intravenous Milrinone and Shenmai Injection， for 7 d and 14 d respectively， in addition to conventional treatment. The clinical effects， NT-proBNP levels， left ventricular ejection fraction （LVEF） and 6 min walking distance were observed before and after treatment for 2 weeks in the two groups. Results 2 weeks after treatment， the total effective rate in observation group was better than that in conventional group， the plasma NT-proBNP level in observation group was declined more obviously than that in conventional group， LVEF and prolong 6 min walking distance were increased more obviously than those in conventional group. Differences between the two groups were statistically significant （P 0.05）. Conclu