腹腔镜下良性卵巢囊肿剥除术对卵巢功能远期影响临床研究.docVIP

腹腔镜下良性卵巢囊肿剥除术对卵巢功能远期影响临床研究 　　【摘要】 目的 探讨腹腔镜下良性卵巢囊肿剥除术对卵巢功能的远期影响。方法 45例行腹腔镜下良性卵巢囊肿剥除术的患者作为腹腔镜组， 32例行开腹良性卵巢囊肿剥除术的患者作为开腹组， 采用酶联免疫吸附试验（ELISA）法分别检测两组患者术后3、6个月血雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）的表达， 观察患者月经规律、月经量、潮热盗汗出现情况及受孕情况。结果 术后3个月， 腹腔镜组FSH水平、月经量减少及潮热盗汗发生率低于开腹组（P0.05）；术后6个月， 腹腔镜组E2水平、受孕率高于开腹组（P0.05）， FSH水平、月经量减少、潮热盗汗发生率低于开腹组（P0.05）。结论 术后远期追踪结果显示， 随时间递增， 行两种手术方法治疗的患者在性激素分泌、月经症状表现及受孕率方面均有不同程度恢复， 但腹腔镜手术明显优于开腹手术。 　　【关键词】 腹腔镜手术；良性卵巢囊肿；卵巢功能 　　DOI：10.14163/j.cnki.11-5547/r.2016.15.008 　　【Abstract】 Objective To investigate long-term influence by laparoscopic benign ovarian cyst enucleation on ovarian function. Methods There were 45 patients receiving laparoscopic benign ovarian cyst enucleation as laparoscope group and 32 patients receiving laparotomy benign ovarian cyst enucleation as laparotomy group. Enzyme-linked immuno sorbent assay （ELISA） was applied to detect estradiol （E2）， follicle-stimulating hormone （FSH）， and luteinizing hormone （LH） in postoperative 3 and 6 months. Observation was made on menstrual cycle， menstrual blood volume， tidal fever， night sweating and pregnancy condition. Results In postoperative 3 months， the laparoscope group had lower PSH level， decreased menstrual blood volume， and incidence of tidal fever and night sweating than the laparotomy group （P0.05）. In postoperative 6 months， the laparoscope group had higher E2 level， decreased menstrual blood volume and pregnancy rate than the laparotomy group （P0.05）， and its FSH level and incidence of tidal fever and night sweating were lower than the laparotomy group （P0.05）. Conclusion Postoperative long-term follow-up shows various recovery degree in sexual hormones secretion， menstrual symptom and pregnancy rate after operational treatment， and laparoscopic surgery contains much better effect than laparotomy. 　　【Key words】 Laparoscopic surgery； Benign ovarian cyst； Ovarian function 　　卵巢囊肿是妇科常见疾病之一， 随着腹腔镜手术技术的应用和发展， 手术适应证的扩大， 腹腔镜手术的应用已经成为卵巢良性囊肿首选手术方式[1]。本课题组前期研究结果显示， 腹腔镜手术治疗良性卵巢囊肿， 腹壁切口小、住院时间短、康复快、安全可