半夏厚朴汤合黄芪建中汤加减治疗癔球症（脾虚肝郁证）的临床观察-中医内科临床专业论文.docx

成都中医 成都中医药大学硕士论文 万方数据 万方数据 中文摘要 目的： 通过半夏厚朴汤合黄芪建中汤加减治疗咽部异常感觉症（咽部神经 官能症、癔球症）（脾虚肝郁证）的临床试验研究，观察其临床疗效和安全性。 方法： 将成都中医药大学附属医院门诊收集的符合癔球症诊断标准和中医脾 虚肝郁证型的 80 例患者随机分为治疗组和对照组各 40 例。治疗组以半夏厚朴汤 合黄芪建中汤加减治疗，并根据临床症状进行加减；对照组以氟哌噻吨美利曲辛 片治疗。两组疗程均为 8 周。停药后比较两组治疗前后的临床症状积分（咽部胀 满、受压等不适，情绪抑郁，急躁易怒，食少纳呆，胸部满闷，胁肋胀痛，眠差， 腹痛即泻、泻后痛减等症状）和两组药物的不良反应及三大常规、肝肾功和心电 图的检查结果的变化，随访 3 个月观察两组患者的复发情况。 结果： 治疗组总有效率 100%，治疗组与对照组的治疗后效果积分比较有显 著统计学差异（p0.01），治疗组优于对照组。治疗组与对照组复发率比较有显 著统计学差异（p0.01），治疗组复发率低于对照组。治疗组与对照组均未见不 良反应。治疗组患者咽部不适及情绪波动等症状缓解情况优于对照组。 结论： 半夏厚朴汤合黄芪建中汤加减治疗癔球症（脾虚肝郁证）有显著疗 效，优于对照组，试验过程中未见不良反应。 关键词： 癔球症 半夏厚朴汤合黄芪建中汤 脾虚肝郁 临床观察 1 To Observe the Clinical Effects and Safety of Modified Ban Xia Hou Po Decoction and Huang Qi Jian Zhong Decoction in Treatment of Globus Hystericus with Spleen Deficiency Syndrome and Stagnation of Liver Qi Abstract Objective: To observe the clinical effects and safety of modified ban xia hou po decoction and huang qi jian zhong decoction in treatment of globus symptom(pharyngeal neurosis,globus hystericus) with spleen deficiency syndrome and stagnation of liver qi. Methods: Select 80 patients with globus hystericus (stagnation of liver qi and spleen deficiency syndrome) from Hospital of Chengdu University of Traditional Chinese Medicine,which were randomly divided into treatment group and control group，40 patients each. The treatment group was treated with modified ban xia hou po decoction and huang qi jian zhong decoction ，and the control group was treated with Flupentixol and Melitracen Tablets ,with eight weeks as the course of which .There were integral level of clinical symptoms such as the abnormal sense of pharyngeal ,depression or irritability,eating less food ， no appetite ， chest full of stuffy ， chest pain and fullness ,poor sleep ,and abdominal distension for globus hystericus.There were the difference between before and after the two different treatment of three routine examinations ， liver function ， renal function and electrocardiogram .There we