肠易激综合征与结肠慢性炎症相关性研究.docVIP

肠易激综合征与结肠慢性炎症相关性研究 　　【摘要】 目的 探索肠易激综合征（IBS）与结肠慢性炎症之间的关系。方法 106例IBS患者， 未合并结肠炎症患者（无炎症组）52例， 合并结肠慢性炎症患者（有炎症组）54例， 对两组临床表现、性质、病变严重程度等方面进行比较， 分析两者的相关性。结果 无炎症组患者腹痛、腹泻、便秘、干稀交替、上腹压痛、中腹压痛、下腹压痛情况与有炎症组患者比较差异无统计学意义（P0.05）。无炎症组患者症状程度指数、症状频率指数分别为（3.78±1.46 ）、（3.95±1.04）， 有炎症组患者分别为（3.54±1.15）、（3.78±0.78）；两组症状程度指数和症状频率指数比较差异无统计学意义（P0.05）。内镜下有炎症组患者炎症轻、中、重度分别为32、22和0例， 而无炎症组均为0例， 比较差异有统计学意义（P0.05）。病理组织学有炎症组患者炎症轻、中、重度分别为30、22、2例， 而无炎症组分别为6、1、0例， 无炎症45例， 比较差异有统计学意义（P0.05）。IBS多合并结直肠轻中度炎症， 重度炎症罕见（P0.01）。结论 IBS的发生与慢性结肠炎症相关， 多表现为轻中度炎症。 　　【关键词】 肠易激综合征；内镜；病理学；结肠慢性炎症 　　DOI：10.14163/j.cnki.11-5547/r.2017.08.019 　　【Abstract】 Objective To explore the correlation between irritable bowel syndrome （IBS） and colon chronic inflammation. Methods Among 106 IBS patients， there were 52 non colonic inflammation patients （non inflammation group） and 54 colon chronic inflammation patients （inflammation group）. Comparison were made on clinical manifestations， nature， disease severity in two groups， and analysis was made on their correlation. Results The non inflammation group had no statistically significant difference in stomachache， diarrhea， constipation， dry thin alternating， epigastric tenderness， center abdomen tenderness and lower abdomen tenderness comparing the inflammation group （P0.05）. The non inflammation group had symptoms degree index and symptoms frequency index respectively as （3.78±1.46 ） and （3.95±1.04）， which were （3.54±1.15） and （3.78±0.78） in inflammation group. Both groups had no statistically significant difference in symptoms degree index and symptoms frequency index （P0.05）. The inflammation group group had mild， moderate and severe inflammation respectively as 32， 22 and 0 case by endoscope， which were all 0 case in non inflammation group， and the difference had statistical significance （P0.05）. The inflammation group group had mild， moderate and severe inflammation respectively as 30， 22 and 2 cases by pathologic histology， which were 6， 1， 0 case and 45 non inflammation cases