胃蛋白酶原Ⅰ联合胃泌素―17检测对慢性萎缩性胃炎发病部位及胃癌进展时期预测价值.docVIP

胃蛋白酶原Ⅰ联合胃泌素―17检测对慢性萎缩性胃炎发病部位及胃癌进展时期预测价值 　　[摘要] 目的 探讨胃蛋白酶原Ⅰ（PGⅠ）联合胃泌素-17（G-17）检测对慢性萎缩性胃炎发病部位及胃癌进展时期的预测价值。 方法 选择本院收治的慢性萎缩性胃炎患者33例、胃癌患者35例作为研究对象，进行PGⅠ、PGⅡ和G-17检测，比较并分析PGⅠ、PGⅡ及G-17水平的变化情况。 结果 慢性萎缩性胃炎组PGⅠ和G-17水平高于胃癌组，差异有统计学意义（P0.05），胃窦部组的PGⅠ水平高于胃体部组和全胃弥漫组，差异有统计学意义（P0.05），胃体部组的G-17水平高于全胃弥漫组和胃窦部组，差异有统计学意义（P0.05），早期胃癌或原位癌的PGⅠ和G-17水平显著高于进展期胃癌，差异有统计学意义（P0.05）。 结论 胃窦部发病为主的慢性萎缩性胃炎其G-17显著下降，胃体部或全胃病变者PGⅠ的下降更加明显，进展期胃癌者PGⅠ水平更低而G-17水平更高。 　　[关键词] 胃蛋白酶原Ⅰ；胃泌素-17；预测；慢性萎缩性胃炎部位；胃癌进展 　　[中图分类号] R446.11+9 [文献标识码] A [文章编号] 1674-4721（2014）09（a）-0126-03 　　The prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer progression 　　ZHOU Hai-ping 　　Department of Elderly Cadre，People′s Hospital of Yichun City in Jiangxi Province，Yichun 336000，China 　　[Abstract] Objective To investigate the prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer progression. Methods 33 cases with chronic atrophic gastritis and 35 cases in the different period of gastric cancer in our hospital were selected as research objects.All these participants were detected by pegsinogenⅠ，pegsinogenⅡ and gastrin-17.The level of pegsinogenⅠ，pegsinogenⅡ and gastrin -17 were compared and analyzed. Results The level of pepsinogens I and gastrin-17 in chronic atrophic gastritis group were higher than that in gastric cancer group，with statistical difference（P0.05）.Pepsinogen I level in the gastric antrum of chronic atrophic gastritis was higher than that in the gastric body and the total diffuse，with statistical difference（P0.05），the gastrin-17 level in the gastric body was higher than that in the total diffuse and in the gastric antrum，with statistical difference（P0.05）.Pepsinogen I and gastrin-17 lever of early gastric cancer and carcinoma in situ were higher than advanced gastric carcinoma，with statistical difference（P0.05）. Conclusion The gastrin-17 in gastric