肠溶阿司匹林治疗冠心病临床疗效及其诱发上消化道出血相关因素分析.docVIP

肠溶阿司匹林治疗冠心病临床疗效及其诱发上消化道出血相关因素分析 　　[摘要] 目的 探究并分析肠溶阿司匹林治疗冠心病的临床疗效及其诱发上消化道出血的相关因素。 方法 回顾性分析我院自2013年12月～2014年12月收治的224例冠心病患者，所有患者均采用肠溶阿司匹林进行治疗，分析经阿司匹林治疗后心绞痛、心肌缺血和缺氧发作的时间的改善情况，并对年龄、消化性溃疡等因素及生活习惯对上消化道出血的影响进行探究。 结果 该组患者治疗前后心绞痛、心肌缺血、心肌缺氧发作时间比较差异均有统计学意义（t=3.45，P0.05；t=2.98，P0.05；t=3.02，P0.05）。患者中年龄大于70岁的患者、合并消化性溃疡的患者和未联合使用胃黏膜保护剂的患者出现上消化道出血的人数与年龄小于70岁、无消化性溃疡患者和联合使用胃黏膜保护剂而发生上消化道出血的人数相比明显偏高，酗酒的患者发生上消化道出血的患者明显多于不酗酒的患者，差异有统计学意义（P0.05），由此可见年龄、是否合并消化性溃疡、是否联合胃黏膜保护剂、是否酗酒是上消化道出血的危险因素。 结论 采用肠溶阿司匹林对冠心病进行治疗可有效缓解心绞痛等症状，但对于年龄较大、并发消化道溃疡并且未联合胃黏膜保护剂进行治疗和生活习惯较差的患者并发上消化道出血的几率更大，可为临床上对疾病的治疗提供依据，减轻患者的痛苦，值得临床推广。 　　[关键词] 肠溶阿司匹林；冠心病；上消化道出血；相关因素；临床疗效 　　[中图分类号] R541.4；R573.2 [文献标识码] B [文章编号] 2095-0616（2015）15-101-04 　　[Abstract] Objective To explore and analyze the clinical efficacy of aspirin therapy for coronary heart disease and its related factors induced upper gastrointestinal bleeding. Methods A retrospective analysis of our hospital from December 2013 to December 2014 were treated 224 cases of coronary heart disease patients， all patients were treated with aspirin treatment， analysis after aspirin treatment of angina pectoris， myocardial ischemia and hypoxia episodes time to improve the situation， and age， and lifestyle factors such as peptic ulcer， upper gastrointestinal bleeding on the impact of inquiry. Results The group of patients before and after treatment of angina pectoris， myocardial ischemia， myocardial ischemia onset were significantly different compared （t=3.45， P0.05； t=2.98， P0.05； t=3.02， P0.05）. Patients with patients older than 70 years， patients and patients without mucosal protective agent in combination merger peptic number of upper gastrointestinal bleeding occurs with age less than 70， no patients with peptic ulcer and gastric mucosal protective agent in combination The number on the occurrence of gastrointestinal bleeding is significantly higher compared to patients with upper gastrointestinal bleeding in patients with alcoholism occurred significantly more than pati