腹腔镜胃癌根治术治疗进展期胃癌效果及对细胞免疫功能影响.docVIP

腹腔镜胃癌根治术治疗进展期胃癌效果及对细胞免疫功能影响 　　【摘要】 目的：探讨腹腔镜胃癌根治术治疗进展期胃癌的效果。方法：选取2011年2月-2015年6月笔者所在医院收治的43例进展期胃癌患者行腹腔镜胃癌根治术治疗，设为研究组；同期43例患者行开腹胃癌根治术治疗，设为对照组。对比两组患者术中、术后情况、住院时间及手术前后细胞免疫功能的差异。结果：研究组切口长度、术中出血量分别为（6.23±2.34）cm、（131.46±22.35）ml，均优于对照组（P0.05）；研究组术后排气时间、住院时间均短于对照组（P0.05），研究组CD4+、CD4+/CD8+均比对照组高（P0.05）。结论：腹腔镜胃癌根治术治疗进展期胃癌效果好，切口小，恢复快，能有效保护免疫功能，值得临床推广。 　　【关键词】 进展期胃癌； 胃癌根治术； 细胞免疫功能； 腹腔镜 　　中图分类号 R735.2 文献标识码 A 文章编号 1674-6805（2016）16-0013-02 　　【Abstract】 Objective：To investigate the effect of laparoscopic radical gastrectomy in the treatment of advanced gastric cancer.Method：43 patients with advanced gastric cancer who underwent laparoscopic gastric cancer radical surgery in our hospital from February 2011 to June 2015 were selected，set as research group，during the same period，43 patients were treated with open radical gastrectomy for gastric cancer，set as control group.Compared with the two groups of patients in the operationpostoperative conditions，length of stay and the difference between the pre and post operation，the cell immune function.Result：Research group，incision length，bleeding volume were （6.23±2.34）cm，（131.46±22.35）ml，which were better than those of the control group（P0.05）；the postoperative exhaust time and hospital stay of the research group were shorter than those of the control group（P0.05）；the CD4+，CD4+/CD8+ of the research group were higher than those in control group（P0.05）.Conclusion：Laparoscopic radical gastrectomy in the treatment of advanced gastric cancer has good curative effect，small incision，quick recovery，and can effectively protect the immune function. 　　【Key words】 Advanced gastric cancer； Radical operation of gastric cancer； Cellular immune function； Laparoscopy 　　First-author’s address：The 95th Hospital of Chinese People’s Liberation Army，Putian 351100，China 　　doi：10.14033/ki.cfmr.2016.16.006 　　进展期胃癌是指癌组织已侵入胃壁肌层、浆膜层，患者预后较差，死亡率高[1-2]。胃癌根治术是治疗进展期胃癌的最有效方式，与传统开腹手术比较，腹腔镜手术创伤小、恢复快，但对机体免疫功能的改变及远期预后的影响尚在探索中[3]。为探讨腹腔镜胃癌根治术治疗进展期胃癌的效果及对细胞免疫功能的影响，笔者所