耐甲氧西林金黄色葡萄球菌耐药性及分布研究.docVIP

耐甲氧西林金黄色葡萄球菌耐药性及分布研究 　　【摘要】 　　目的:了解临床科室耐甲氧西林金黄色葡萄球菌（MRSA）的分离率及其耐药情况，掌握MRSA在临床科室分布的特点，为预防、控制MRSA的医院感染提供科学依据。方法:对本院2011年1―5月份临床标本中分离的MRSA及其药物敏感结果进行统计、分析。结果:195株金黄色葡萄球菌中MRSA 94株，占金黄色葡萄球菌感染总数的48.2%。94株MRSA均对万古霉素及利奈唑烷敏感，对利奈唑胺、氯霉素、复方新诺明耐药率较低，对其他抗菌药物均有很高的耐药率。MRSA在住院科室分布依次为外科系统、ICU病房、内科系统。结论:本院MRSA检出率为48.2%，对万古霉素、利奈唑胺、氯霉素耐药率分别为0、0及8.51%。MRSA表现为多重耐药性，外科系统与ICU病房MRSA感染率较高，可能与临床科室进行创伤性诊断及治疗操作、不合理使用抗生素及患者的基本情况有关。 　　【关键词】耐甲氧西林金黄色葡萄球菌;检出率; 耐药性; 分布 　　【Abstract】 Objective: To investigate the separation rate and drug resistance of meticillin resistant staphylococcus aureus (MRSA) for clinical departments, and to master the distribution features of MRSA in clinical departments, so as to provide scientific basis for preventing and controlling hospital infection of MRSA. Method: To collect and analyze the MRSA separated from clinical specimens from Jan to May in 2011 of our hospital and its drug sensitive results. Result: 94 strains of MRSA exist in 195 strains of staphylococcus aureus, occupying 48.2% of the total number of staphylococcus aureus infection. The 94 strains of MRSA are all sensitive to vancomycin and linezolid, while the drug resistance rate of 94 strains of MRSA to linezolid, chloramphenicol and SMZ-TMP keeps in a lower level and to other antibacterial agents in a very high level. The distribution of MRSA in hospital departments exists in surgery systems, ICU and internal medicine systems. Conclusion: The relevance ratio of MRSA in our hospital is 48.2%, the drug resistance rates of MRSA to vancomycin, linezolid and chloramphenicol are respectively 0, 0 and 8.51%. MRSA shows multiple drug resistance, the infection rate of MRSA is higher in surgery systems and ICU, which might relates to traumatic diagnosis and treatment by the clinical department, irrational use of antibiotics as well as patients’ basic conditions. 　　【Key Words】meticillin resistant staphylococcus aureus, relevance ratio, drug resistance, distribution 　　【中图分类号】R365.1 【文献标识码】B 【文章编号】1005-0515(2011)1