药学干预对肿瘤患者丙氨酰谷氨酰胺使用效果分析.docVIP

药学干预对肿瘤患者丙氨酰谷氨酰胺使用效果分析 　　[摘要]目的 探讨药学干预对肿瘤患者丙氨酰谷氨酰胺的使用效果。方法 选取2016～2017年我院使用丙氨酰谷氨酰胺治疗的904例肿瘤患者作为研究对象，2016年的662例住院肿瘤患者作为干预前组，2017年的药学干预期间使用丙氨酰谷氨酰胺治疗的242例住院肿瘤患者作为干预后组。收集干预前后的病例资料，比较干预前后临床使用该药的合理性情况。结果 干预后，丙氨酰谷氨酰胺应用于肿瘤患者肠外营养的平均使用疗程短于干预前，差异有统计学意义（P0.01）。干预后不合理用药率明显少于干预前，差异有统计学意义（P0.01）。干预后，超适应证用药、配制浓度过高、用药疗程过长的不合理率均低于干预前，差异有统计学意义（P0.01）。结论 对肿瘤患者丙氨酰谷氨酰胺的使用进行药学干预，使其临床用药规范合理，表明药学干预是可行有效的。 　　[关键词]药学干预；丙氨酰谷氨酰胺；肿瘤患者；合理使用；肠外营养 　　[中图分类号] R151.41 [文献标识码] A [文章编号] 1674-4721（2017）10（c）-0079-04 　　Analysis of effect of pharmaceutical intervention on the use of Alanyl-glutamine in patients with tumor 　　LIN Yan WU Kun-sheng QIU Yong-jun▲ ZHU Min-fang LI Ke 　　Department of Pharmacy，Shangrao People′s Hospital，Jiangxi Province，Shangrao 334000，China 　　[Abstract]Objective To investigate the effect of pharmaceutical intervention on the use of Alanyl-glutamine in patients with tumor.Methods From 2016 to 2017，a total of 904 patients with tumor were treated with Alanyl-glutamine in our hospital were selected as the research objects.662 cases of hospitalized patients with tumor in 2016 were selected as before intervention group，242 patients with inpatient tumors treated with Alanyl-glutamine were treated as after intervention group in the course of the pharmaceutical intervention in 2017.The case data before and after the intervention were collected，and the rationality of the clinical use of Alanyl-glutamine before and after the intervention were compared.Results After intervention，the average treatment course of Alanyl-glutamine in patients with tumor was shorter than before intervention，and the difference was statistically significant （P0.01）.After intervention，the rate of unreasonable drug use was significantly less than before intervention，and the difference was statistically significant （P0.01）.After intervention，the unadjusted rate of medication beyond the indication，preparation of high-concentration medication and overlong course of medication treatment after the intervention were