药物联合高压氧在治疗重度眼化学伤中疗效观察.docVIP

药物联合高压氧在治疗重度眼化学伤中疗效观察 　　【摘要】 目的 探讨高压氧（HBO）在治疗重度眼化学伤中的治疗要点和临床效果。方法 47例（49眼）重度眼化学伤（Ⅲ～Ⅳ度）患者， 根据不同治疗方法分为单纯药物治疗组（A组）和药物联合高压氧治疗组（B组）， A组23只眼， 单纯采用药物治疗， B组26只眼， 采用HBO联合药物治疗， 随访3个月。观察两组疗效， 对治疗后角膜透明度恢复、角膜新生血管增殖情况及最佳矫正视力（BCVA）进行分析比较。结果 角膜透明度（U=-2.210， P=0.0270.05）、角膜新生血管增殖情况（U=-3.153， P=0.0020.05）及最佳矫正视力（t=-2.172， P=0.0390.05）B组患者均优于A组， 两组比较差异有统计学意义（P0.05）。结论 药物联合高压氧治疗重度眼化学伤效果优于单纯药物治疗， 可供临床选用。 　　【关键词】 化学伤；高压氧；眼 　　DOI：10.14163/j.cnki.11-5547/r.2015.19.024 　　Curative effect observation of drug combined with hyperbaric oxygen in the treatment of severe ocular chemical injury JIAO Yong-fa， ZHANG Qing-fen. Department of Ophthalmology， Linyi City Yishui Central Hospital， Linyi 276400， China 　　【Abstract】 Objective To investigate treatment focus and clinical effect of hyperbaric oxygen （HBO） in the treatment of severe ocular chemical injury. Methods A total of 49 eyes （47 cases） patients with severe ocular chemical injury （grade Ⅲ～Ⅳ） were divided by different treatment methods into single drug therapy group （group A） and drug combined with hyperbaric oxygen treatment group （group B）. Group A with 23 eyes received single drug therapy， and group B with 26 eyes received HBO combined with drug therapy. Follow-up lasted for 3 months. Curative effects of the two groups were observed， and corneal transparency recovery， corneal neovascularization proliferation， and best corrected visual acuity （BCVA） after treatment were all analyzed and compared. Results The group B had all better corneal transparency （U=-2.210， P=0.0270.05）， corneal neovascularization proliferation （U=-3.153， P=0.0020.05）， and best corrected visual acuity （t=-2.172， P=0.0390.05） than group A. The differences between the two groups had statistical significance （P0.05）. Conclusion Combination of drug and HBO can provide better curative effect in treating severe ocular chemical injury than single drug therapy， and this method is worth clinical application. 　　【Key words】 Chemical injury； Hyperbaric oxygen； Eye 　　眼化学伤临床