葛根素联合胞磷胆碱钠治疗突发性耳聋临床观察.docVIP

葛根素联合胞磷胆碱钠治疗突发性耳聋临床观察 　　[摘要] 目的 探讨葛根素联合胞磷胆碱钠治疗突发性耳聋的临床效果。 方法 将入组的62例患者随机分为治疗组32例与对照组各30例，治疗组用葛根素注射液联合胞磷胆碱钠注射液治疗，对照组用葛根素注射液治疗，15 d为1个疗程，观察治疗前后两组的临床总有效率及听阈的改善情况。 结果 两组治疗后总有效率比较，差异有统计学意义（P0.05）；平均听阈差值比较，差异有统计学意义（PO.01）。 结论 葛根素联合胞磷胆碱钠注射液在改善血液循环及营养神经方面有明显作用，是治疗突发性耳聋安全、有效的临床用药。 　　[关键词] 突发性耳聋；葛根素；胞磷胆碱钠 　　[中图分类号] R764.43+7 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0079-02 　　Clinical observation of puerarin combined with citicoline sodium in treatment of sudden deafness 　　HE Qiao-ling 　　Department of Pharmacy，the Second People′s Hospital of Jiaozuo City in Henan Province，Jiaozuo 454150，China 　　[Abstract] Objective To investigate the clinical efficacy of puerarin combined with citicoline sodium in the treatment of sudden deafness.Methods Sixty-two patients were randomly divided into two groups.The treatment group received puerarin injection combined with citicoline sodium injection，the control group received puerarin injection，one treatment course consisted of 15 days.The clinical total effective rate and pure tone tests before and after the treatment were observed.Results After the treatment，the total effective rate of the two groups was significantly different （P0.05） and the average hearing thresholds was also significantly different （P0.01）.Conclusion Puerarin combined with citicoline sodium has obvious effect on improving blood circulation and trophic nerves，and therefore is a safe and effective clinical drug for the treatment of sudden deafness. 　　[Key words] Sudden deafness；Puerarin；Citicoline sodium 　　突发性耳聋是原因不明的突然发生的感音神经性聋，多在3 d内听力急剧下降。临床中治疗突发性耳聋的药物主要选用血管扩张剂，以改善内耳微循环，而单纯应用血管扩张药物疗效相对较差[1]。临床用药方案是为了更好地治疗突发性耳聋、减少不良反应的发生。本院采用葛根素联合胞磷胆碱钠治疗突发性耳聋32例，与单纯应用葛根素治疗的30例突发性耳聋患者作疗效对照，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选取2010年3月～2012年10月本院门诊及住院患者62例，其中，男36例，女26例，与中华医学会耳鼻咽喉科学会1997年4月制订的突发性耳聋诊断标准[2]符合，62例患者均排除高血压、糖尿病、精神疾病、出血性疾病等。将入组的患者随机分为治疗组与对照组，治疗组32例（38耳）中，男17例，女15例；年龄21～68岁，平均42.2岁；病程1～10 d，平均5 d；治疗前的平均听阈为72 dB。对照组30例（33耳）中，男14例，女16例；年龄22～67岁，平均42.8岁；病程2～11 d，平均5.5 d；治疗前的平均听阈为7