视黄醇结合蛋白胱抑素C及β2微球蛋白联检对2型糖尿病早期肾损害诊断价值.docVIP

视黄醇结合蛋白胱抑素C及β2微球蛋白联检对2型糖尿病早期肾损害诊断价值 　　【摘要】 目的：探讨视黄醇结合蛋白（RBP）、胱抑素C（Cys C）及β2微球蛋白（β2-MG）联检对2型糖尿病（T2DM）早期肾损害的诊断价值。方法：将选取的125例T2DM患者根据尿白蛋白排泄率分成正常蛋白尿组（62例）、微量蛋白尿组（63例），另选健康体检人员45例做对照组，所有受检者血清RBP采用免疫透射比浊法检测，Cys C、β2-MG采用颗粒增强免疫透射比浊法检测。结果：微量蛋白尿组血清RBP、Cys C、β2-MG、Urea及Crea含量及阳性率较另外两组高（P0.05）；正常蛋白尿组RBP、Cys C及β2-MG含量及阳性率较对照组高（P0.05）；两试验组RBP、Cys C、β2-MG阳性率较Urea或Crea高（P0.05）；两试验组RBP与Cys C联检的阳性率较单项指标高，RBP、Cys C与β2-MG三项联检时阳性率较RBP与Cys C两项联检高（P0.05）。结论：RBP、Cys C及β2-MG可作为T2DM早期肾损伤诊断的有价值的指标，联合检测意义更大。 　　【关键词】 视黄醇结合蛋白； 胱抑素C； β2微球蛋白； 2型糖尿病； 早期肾损害 　　中图分类号 R587.2 文献标识码 A 文章编号 1674-6805（2014）24-0041-03 　　Diagnostic Value of Retinol Binding Protein，Cystatin C andβ2 Microglobulin in Type 2 Diabetes Mellitus Early Renal Damage/SU Wen-tang，LIU Jing.//Chinese and Foreign Medical Research，2014，12（24）：41-43 　　【Abstract】 Objective：To study the diagnostic value of srum retinol binding protein（RBP），cystatin C（Cys C） and β2 microglobulin（β2-MG） in early renal damage.Method：125 case of T2DM were selected.The urinary albumin excretion rate（UAER） of 62 Patients with T2DM was less than 20 μg/min was normal albuminuria group，the UAER of 63 patients with T2DM was situated between 20 μg/min and 200 μg/min was microalbuminuria group.45 cases of healthy people was control group.RBP was tested by the immune turbidimetric method，Cys C and β2-MG were test by particle enhanced immuno turbidimetric assay.Result：The content and the positive rate of RBP，Cys C，β2-MG、ureaand creatinine in microalbuminuria group were higher than other two groups（P0.05）.The Content and the positive rate of RBP，Cys C，β2-MG in normal albuminuria group were higher than control group（P0.05）.The positive rate of RBP and Cys C was higher than RBP or Cys C（P0.05）.The positive rate of RBP，Cys C or β2-MG in the two experimental group were higher than Urea or Crea（P0.05）.The positive rate of RBP，Cys C and β2-MG in the two experimental group were higher than RBP and Cys C（P0.05）.Conclusion：RBP，Cys C and β2-MG can be used as marker in diagnosi