病理学导论01组织损伤课件.ppt

* This is cardiac hypertrophy involving the left ventricle. The number of myocardial fibers does not increase, but their size can increase in response to an increased workload, leading to the marked thickening of the left ventricle in this patient with systemic hypertension. Pathologic Changes of Hypertrophy The affected organ is enlarged and heavy. There is enlargement of muscle fibres as well as of nuclei. At ultrastructural level, there is increased synthesis of DNA and RNA, increased protein synthesis and increased number of organelles like mitochondria, endoplasmic reticulum and myofibril