输尿管镜下钬激光碎石术对输尿管结石患者应激反应及肾功能影响.docVIP

输尿管镜下钬激光碎石术对输尿管结石患者应激反应及肾功能影响 　　[摘要] 目的 探?输尿管镜下钬激光碎石术对输尿管结石患者应激反应及肾功能的影响。方法 方便选择2014年1月―2016年12月期间在该院治疗的750例输尿管结石患者作为研究对象，根据随机数表法将其分为观察组与对照组，各375例。对照组采用气压弹道碎石术，观察组采用钬激光碎石术，比较两组碎石情况、应激反应及肾功能指标变化。结果 观察组碎石成功率为98.67%、结石排净率为96.80%，均高于对照组的90.40%、84.80%，而输尿管损伤发生率（1.60%）低于对照组（5.60%），差异有统计学意义（P0.05）；术后观察组Cor（241.12±29.03）ng/mL、MDA（6.43±1.55）nmol/L水平低于对照组[（263.87±34.42）ng/mL、（9.85±1.72）nmol/L]，SOD（71.24±16.64）NU/mL水平高于对照组（62.89±14.96）NU/mL，差异有统计学意义（P0.05）；术后1个月观察组Scr（108.52±31.65）μmoL、BUN（4.35±1.06）mmol/L水平低于对照组[（133.34±38.79）μmoL、（6.72±1.19）mmol/L]，差异有统计学意义（P0.05）。 结论 与气压弹道碎石术治疗输尿管结石相比，钬激光碎石术碎石成功率、结石清除率更高，且对输尿管造成的损伤小，引起的应激反应轻，有利于改善患者的肾功能指标，可作为临床治疗输尿管结石的首选术式。 　　[关键词] 输尿管镜下钬激光碎石术；输尿管结石；应激反应；肾功能 　　[中图分类号] R3 [文献标识码] A [文章编号] 1674-0742（2017）08（c）-0021-03 　　Effect of Ureteroscopic Holmium Laser Lithotripsy on the Stress Reaction and Renal Function of Patients with Ureteral Calculus 　　GUO Yi-hong， LI Yi-ning， ZHANG Jian-yu， WANG Jia-liang， MU Xin 　　Department of Urinary Surgery， Second Affiliated Hospital of Fujian Medical College， Quanzhou， Fujian Province， 362000 China 　　[Abstract] Objective To study the effect of ureteroscopic holmium laser lithotripsy on the stress reaction and renal function of patients with ureteral calculus. Methods 750 cases of patients with ureteral calculus treated in our hospital from January 2014 to December 2016 were convenient selected as the research objects and randomly divided into two groups with 375 cases in each， the control group and the observation group were respectively treated with ballistic lithotripsy and holmium laser lithotripsy， and the detritus situation， stress reactions and renal function index changes were compared between the two groups. Results The detritus success rate and stone free rate in the observation group were higher than those in the control group，（98.67%， 96.80% vs 90.40%、84.80%）， and the incidence rate of ureteral injury in the observation group was lower than that in the control group， （1.60% vs 5.60%）， and