针刺结合加味桃红四物汤治疗女性黄褐斑疗效及其对患者雌激素和孕激素影响.docVIP

针刺结合加味桃红四物汤治疗女性黄褐斑疗效及其对患者雌激素和孕激素影响 　　【摘要】 目的：探讨针刺结合加味桃红四物汤治疗女性黄褐斑的效果及其对患者性激素的影响。方法：选取2015年6月-2017年6月在本院就诊的女性黄褐斑（气滞血瘀型）患者90例，按照随机数字表法将其分为观察组和对照组，各45例。对照组采用维生素E及维生素C钠口服治疗，观察组采用针刺结合加味桃红四物汤治疗，两组均以12周为一疗程。比较两组治疗前后色斑面积及颜色评分、皮肤病生活质量指数（DLQI）、孕激素（P）、雌激素（E2）水平，比较两组临床疗效。结果：治疗后观察组色斑面积及颜色、DLQI评分均低于对照组（P0.05）；治疗后观察组E2低于对照组，P高于对照组（P0.05）；观察组总有效率为93.33%（42/45），高于对照组的71.11%（32/45），比较差异有统计学意义（P0.05）。结论：针刺结合加味桃红四物汤治疗女性黄褐斑的效果及其对患者性激素效果显著，可有效改善激素水平，值得推广。 　　【关键词】 针刺； 加味桃红四物汤； 女性黄褐斑； 性激素 　　【Abstract】 Objective：To study the effect of acupuncture combined with Modified Taohong Siwu Decoction on treatment of female chloasma and its effect on sex hormones.Method：90 female patients with chloasma（qi stagnation and blood stasis） were treated in our hospital from June 2015 to June 2017 were selected，according to the random number table method，they were divided into observation group and control group，45 cases in each group.The control group was treated with Vitamin E and Vitamin C Sodium oral therapy，and observation group was treated with acupuncture combined with Modified Taohong Siwu Decoction，they were treated with 12 weeks for 1 course.The pigmentation area and color score，dermatology life quality index（DLQI），progesterone（P） and estrogen（E2） levels of two groups were compared before and after treatment，the clinical efficacy of two groups was compared.Result：After treatment，the pigmentation area and color，DLQI score of observation group were lower than those of control group（P0.05）.After treatment，the E2 of observation group was lower than that of control group，and P was higher than that of control group（P0.05）.The total effective rate of observation group was 93.33%（42/45），higher than 71.11%（32/45） of the control group，the difference was statistically significant（P0.05）.Conclusion：The effect of acupuncture combined with Modified Taohong Siwu Decoction on treatment of female chloasma and its effect on sex hormones in patients is remarkable，which can effectively improve the hormone level an