降钙素原超敏C反应蛋白联合白介素6动态检测在新生儿感染早期诊断中价值.docVIP

降钙素原超敏C反应蛋白联合白介素6动态检测在新生儿感染早期诊断中价值 　　[摘要] 目的 探讨降钙素原、超敏C反应蛋白联合白介素6动态检测在新生儿感染早期诊断中的价值。方法 方便选取该院2015年2月―2017年2月期间新生儿科收治的125例感染性疾病新生儿为观察组，其中75例为细菌感染组，50例为病毒感染组，细菌感染组中重症感染35例，轻症感染40例，并以同期该院收治的50例非感染性疾病新生儿为对照组研究对象。所有新生儿均检测血清降钙素原（PCT）、超敏C反应蛋白（hs-CRP）及白介素6（IL-6）。观察各组新生儿指标检测结果，并以工作特征（ROC）曲线分析3种指标的疾病诊断特异性。结果 细菌感染组患儿PCT、hs-CRP、IL-6各指标均显著高于病毒感染组和对照组新生儿，差??有统计学意义（P0.05）。重症感染组PCT、hs-CRP、IL-6水平明显高于轻症感染组，轻症感染组的3项指标明显高于对照组（P0.05）。PCT、hs-CRP、IL-6 3项指标的ROC曲线下面积分别为85.33、70.12、82.24，灵敏度为74.67%、70.67%、80.00%，特异性为90.67%、66.67%、68.00%。结论 PCT、hs-CRP、IL-6均能作为判定新生儿早期感染的指标之一，但白介素6的灵敏度更高，降钙素原的特异性更好，联合动态检测可以提高诊断的灵敏度和特异性。 　　[关键词] 血清降钙素原；超敏C反应蛋白；白介素6；细菌性感染 　　[中图分类号] R181 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0034-04 　　The Value of Procalcitonin， High Sensitivity C-reactive Protein Combined with Interleukin-6 in the Early Diagnosis of Neonatal Infection 　　TAO Hui-xian 　　Department of Neonatology， the First People’s Hospital of Zhangjiagang， Suzhou， Jiangsu Province， 215600 China 　　[Abstract] Objective This paper tries to investigate the value of procalcitonin， high sensitivity C-reactive protein combined with interleukin-6 in the early diagnosis of neonatal infection. Methods Convenient selected a total of 125 neonates with infectious diseases were enrolled in this hospital from February 2015 to February 2017. Of these， 75 were bacterial infection， 50 were virus infection， and in the group 35 cases of infection， 40 cases of mild infection， and the same period our hospital treated 50 cases of non-infectious diseases of newborns as the control group of subjects. Serum levels of procalcitonin （PCT）， hypersensitive C-reactive protein （hs-CRP） and interleukin-6 （IL-6） were measured in all newborns. The results of each group of neonates were observed， and the disease specificity of the three indexes was analyzed by the working characteristic （ROC） curve. Results The levels of PCT， hs-CRP and IL-6 in children with bacterial infection were significantly higher than those in virus infection group an