降钙索原C反应蛋白在儿童哮喘合并呼吸道感染中诊断意义.docVIP

降钙索原C反应蛋白在儿童哮喘合并呼吸道感染中诊断意义 　　摘要：目的 探讨血清降钙索原（PCT）、C反应蛋白（CRP）对哮喘合并呼吸道感染患儿的诊断价值。方法 对60例哮喘急性发作患儿，根据发病诱因，分为过敏诱发组、病毒诱发组及细菌感染诱发组，采用免疫发光法定量测定患儿血清PCT水平，自动免疫散射速率比浊法测定CRP水平。结果 细菌感染诱发哮喘组患儿PCT、CRP水平（PCT=25.7±11.2 g/L、CRP=50.3±17.5 mg/L）显著高于病毒感染（PCT=0.7±0.2μg/L、CRP=6.1±0.3 mg/L）及过敏诱发哮喘组（PCT=0.2±0.1μg/L、CRP=3.5±0.4 mg/L）患儿（P0.05），诊断价值不明显。细茵感染诱发哮喘组PCT与CRP之间有正相关性（r=3.612，P0.05）；以PCT≥0.5μg/L为界，诊断细菌感染的敏感性92.9%，以CRP≥10mg/L为界，诊断细菌感染的敏感性为89.3%，细菌感染诱发哮喘组血清PCT、CRP阳性率（25/28，89.3%；26/28，92.9%）分别显著高于病毒感染诱发哮喘组（4/14，28.6%；9/14，64.3%）及过敏诱发感染组患儿（4/18，22.2%；6/18，33.3%），病毒感染诱发哮喘组血清PCT、CRP阳性率（4/18，22.2%；6/18，33.3%）均显著高于过敏诱发感染组（4/18，22.2%；6/18，33.3%），差异均具有统计学意义（均P0.05）。结论 血清PCT、CRP指标能早期正确鉴别细菌感染诱发的哮喘急性发作患儿。 　　关键词：哮喘急性发作；降钙素原；c反应蛋白；儿童 　　The diagnostic value of PCT、CRP in children with acute asthma attac 　　Abstract Objective To explore the serum calcium down the original PCT C reactive protein CRP to patients with acute asthma attack diagnostic value.Methods 60 cases with acute asthma attack were divided into allergen-induced group、viral infection-induced group and bacteria infection-induced group. Then by immune shine law quantitatively patients serum PCT level automatic immune scattering rate than turbidity method to determine the CRP level. Results Patients with asthma bacterial infections PCT、CRP level（PCT=25.7±11.2 g/L、CRP=50.3±17.5 mg/L）was significantly higher than the asthma merger virus infection （PCT=0.7±0.2μg/L、CRP=6.1±0.3 mg/L）and allergen-induced（PCT=0.2±0.1μg/L、CRP=3.5±0.4 mg/L） patients（P0.05）.There was positive correlation between PCT and CRP in bacterial infection group（r=3.612，P0.05）.PCT infrequency 0.5g/L as border diagnosis bacterial infections sensity 92.9%，with CRP quartile 10mg/L for world diagnosis of bacteria infection sensitivity of 89.3%. Patients with asthma bacterial infections PCT、CRP positive rates（25/28，89.3%；26/28，92.9%）were significantly higher than the asthma merger virus infection （4/14，28.6%；9/14，64.3%） and allergen-induced （4/18，22.2%；6/18，，33.3%） patients （P