重度支气管哮喘患者应用噻托溴铵临床研究.docVIP

重度支气管哮喘患者应用噻托溴铵临床研究 　　[摘要] 目的 研究重度支气管哮喘患者应用噻托溴铵的临床疗效。 方法 A组患者在基线治疗基础上应用噻托溴铵粉吸入治疗，B组患者应用基线治疗。治疗完成后比较两组临床疗效，两组治疗前后FEV1、FEV1占预计值百分比和用力肺活量、呼气峰流速、FEV1与FVC的比值等数值。 结果 研究A组总有效率为91.18%，显著高于研究B组的60.29%（P0.05）。两组治疗后FEV1、FEV1%、FVC、PEF及FEV1/FVC均显著优于治疗前，研究A组优化幅度显著优于研究B组（P0.05）。两组治疗后FEV1支气管扩张试验增加绝对值、圣乔治评分均显著优于治疗前，研究A组优化幅度显著优于研究B组（P0.05）。 结论 重度支气管哮喘患者应用噻托溴铵疗效更为显著，且可有效改善肺功能，优化支气管哮喘患者生活质量。 　　[关键词] 支气管哮喘;噻托溴铵;沙美特罗;肺功能 　　[中图分类号] R562.25 [文献标识码] B [文章编号] 2095-0616（2015）02-40-04 　　Clinical study of tiotropium bromide applied to patients with serious bronchial asthma 　　SHAO Ying1，2 TAN Mingqi3 　　1. Department of Respiratory， Liaoning Power Central Hospital， shenyang， 110002， China; 2. Department of Respiratory，Shengjing Hospital of China Medical University， Shenyang 110004，China;3. Second Department of Respiratory， Shengjing Hospital of China Medical University，shenyang 110004， China 　　[Abstract] Objective To study the clinical effect of tiotropium bromide applied to patients with serious bronchial asthma. Methods To compare the clinical effect of the two groups after treatment and to compare FEV1， the percentage of FEV1 in predicted value， forced vital capacity （FVC）， peak expiratory flow （PEF）， and FEV1/FVC pre and post treatment between the two groups， while A group was treated with tiotropium bromide based on baseline treatment and B group was treated with baseline treatment. Results The total effective rate in A group （91.18%） was significantly higher than in B group （60.29%） （P0.05）. FEV1， FEV1%， FVC， PEF， and FEV1/FVC post-treatment were significantly better than pre-treatment， while which in A group were significantly better than in B group（P0.05）. The absolute augmented value of FEV1 bronchiectasis test and the St.Georges respiratory questionnaire （SGRQ） score post-treatment were significantly better than pre-treatment， while which in A group were significantly better than in B group（P0.05）. Conclusion Tiotropium bromide applied to patients with serious bronchial asthma h