重症患者血清甲状腺素水平与APACHEII评分相关性研究.docVIP

重症患者血清甲状腺素水平与APACHEII评分相关性研究 　　doi：10.3969/j.issn.1007-614x.2014.21.65 　　摘 要 目的：探讨重症患者血清甲状腺素水平与APACHEII评分的相关性。方法：2011年10月-2012年12月收治重症患者80例，根据病情的严重程度分为轻、中、重度3组。Ⅰ组27例，为轻度重症患者；Ⅱ组23例，为中度重症患者；Ⅲ组30例，为重度重症患者。观察3组血清甲状腺素水平变化，同时进行APACHEⅡ评分，观察血清甲状腺素变化水平与病情严重程度、APACHEⅡ评分和预后的关系。结果：中重度重症患者较轻度重症患者的甲状腺素水平低（P0.05），具有统计学意义。中重度重症患者较轻度重症患者的APACHEII评分高（P0.05），具有统计学意义。结论：血清甲状腺素越低患者的病情越严重，APACHEⅡ评分越高，预后越差。 　　关键词 重症患者 甲状腺素 APACHEⅡ评分 相关性研究 　　Study critical patients serumThyroid hormone levels correlation with APACHEⅡ score 　　Guan Ruining，Zhou Mudan，Yu Dongzai，Tan Jiaxiang 　　Department of Breath Internal Medicine，the Central Hospital of Kaiping City，Guangdong 529300 　　Abstract Objective：To explore and analysis the severe serum thyroxine levels and APACHEⅡ score.Methods：80 cases of critically ill were admitted from October 2011 to December 2012 in our hospital.According to thethe severity of the disease，they were divided into mild，moderate and severe groups.I group of mild were 27 cases.Ⅱ group of moderate were 23 cases.Ⅲ group of severe were 30 cases.Observe changes in serum thyroxine levels of the three groups，while APACHEII score was observed changes in serum thyroxine levels with the severity of the disease，the APACHE Ⅱ score and prognosis.Results：The level of thyroxine of the moderate and severe group was lower than that of the mild group. The difference was statistically significant（P0.05）.APACHEⅡ score of the moderate and severe group was higher than that of the mild group.The difference was statistically significant（P0.05）.Conclusion：According to the experimental analysis of serum thyroxine lower the patients condition more serious higher score APACHEⅡ，the worse the prognosis. 　　Key words Critical patients；Thyroxine；APACHEⅡ score；Correlational study 　　重症患者是指病情危重，必须在短时间内进行治疗的患者。一般重症患者在开始治疗时需要急诊抢救，在治疗过程中要及时通知家属患者的病情[1]。甲状腺素是甲状腺激素的一类，是一种在甲状腺球蛋白内碘化酪氨酸分子的耦联而形成的碘化的酪氨酸衍生物，是由甲状腺内囊状小泡分泌的[2]。它的主要作用是能影响代谢的速度和耗氧的速率。在临床上常用于甲状腺功能减退和单纯性甲状腺肿等疾病。APACHEⅡ评分就是急性生理和慢性健康状况的评价，其主要作用是检测急性生理的异常变化情况