阿托伐他汀联合氨氯地平对高血压冠心病血液动力学心电图特点及药物安全性研究.docVIP

阿托伐他汀联合氨氯地平对高血压冠心病血液动力学心电图特点及药物安全性研究 　　[摘要] 目的 探讨阿托伐他汀联合氨氯地平对于高血压冠心病的临床治疗效果。 方法 回顾分析2016年1月～2017年1月在我院接受治疗的高血压冠心病患者80例，根据治疗方法的不同平均分为实验组（阿托伐他汀联合氨氯地平）和对照组（氨氯地平）。通过治疗前和治疗2个月后的血压、血脂的指标以及心电图的改善情况将两组疗效进行对比，观察两组不良反??率。 结果 治疗后，实验组收缩压和舒张压[（123.7±6.1）mmHg、（69.1±5.3）mmHg]显著低于对照组[（138.6±7.1）mmHg、（76.8±5.4）mmHg]，实验组血脂[TG（1.8±0.3）mmol/L，TC（3.5±0.7）mmol/L，LDL-C（1.6±0.5）mmol/L]显著低于对照组[（2.1±0.4）mmol/L，（4.0±0.6）mmol/L，（1.9±0.4）mmol/L]，HDL-C[（1.4±0.2）mmol/L]显著高于对照组[（1.1±0.2）mmol/L]，组间差异显著（P0.05）。 结论 使用阿托伐他汀与氨氯地平联合治疗对于高血压冠心病相比于单独使用氨氯地平治疗其临床效果更加显著，且副作用发生率同样较低，对于血压和血脂水平改善效果显著，对于高血压冠心病具有十分重要的使用价值。 　　[关键词] 冠心病；氨氯地平；阿托伐他汀；高血压 　　[中图分类号] R544.1；R541.4 [文献标识码] B [文章编号] 1673-9701（2018）09-0076-03 　　Hemodynamic， electrocardiographic characteristics and drug safety of atorvastatin combined with amlodipine in patients with hypertensive coronary heart disease 　　XU Yikang 　　Department of Cardiovascular Diseases CCU， Second Affiliated Hospital of Shenyang Medical College， Shenyang 110001， China 　　[Abstract] Objective To observe the treatment effect of atorvastatin combined with amlodipine on hypertensive coronary heart disease. Methods 80 patients with hypertensive coronary heart disease who were treated in our hospital from January 2016 to January 2017 were retrospectively analyzed. The patients were divided into experimental group （atorvastatin combined with amlodipine） and control group（amlodipine） according to the different treatment methods. The efficacy between two groups was compared through the improvement of blood pressure， blood lipids and electrocardiogram before and after treatment for two months. The adverse reactions of two groups were observed. Results After treatment， systolic blood pressure（123.7±6.1） mmHg and diastolic blood pressure （69.1±5.3） mmHg in the experimental group were significantly lower than those in the control group[（138.6±7.1）mmHg and （76.8±5.4）mmHg]. The blood lipids TG（1.8±0.3）mmol/L，TC（3.5±0.7）mmol/L，LDL-C（1.6±0.5）mmol/L were significantly lower than those