雾化吸入万托林与普米克令舒治疗儿童支气管哮喘急性发作临床观察.docVIP

雾化吸入万托林与普米克令舒治疗儿童支气管哮喘急性发作临床观察 　　【摘要】目的：探讨氧气驱动雾化吸入普米克令舒、万托林联合治疗儿童哮喘急性发作的疗效。方法：将112例儿童哮喘急性发作患儿随机分为对照组58例和治疗组54例。对照组静脉滴入地塞米松、氨茶碱，治疗组氧气驱动雾化吸入普米克令舒、万托林，观察比较两组的疗效和不良反应。结果：症状缓解、总显效率、肺功能改善情况，治疗组与对照组疗效比较差异有显著性( P0.01)，且未发现明显不良反应。结论：应用氧气驱动雾化吸入普米克令舒、万托林为目前治疗儿童哮喘急性发作为安全有效的方法。 　　【关键词】普米克；万托林；雾化吸入；哮喘；儿童 　　文章编号：1009-5519（2007）18-2695-02 中图分类号：R72 文献标识码：A 　　Clinical observation of aerosol inhalation of ventolin and pulmicort respulses in acute attack of bronchial asthma in children 　　YIN Shan-hui，WANG Gang，LI Ying-qing 　　(Department of Respiration，The First Affiliated Hospital of Nanhua University，Hunan 421001，China) 　　【Abstract】Objective：To study the effect of aerosol inhalation of ventolin and pulmicort respulses in acute attack of bronchial asthma in children.Methods:112 sick children with acute attack of bronchial asthma were randomly divided into the control group(58 cases) and treatment group(54 cases).The control group received dexamethasone and aminophylline by intravenous drip,while the treatment group received pulmicort respulses and ventolin by driving aerosol inhalation.The curative effect and side effects were observed and compared between two group.Results:The significant differenece was seen between two groups after treatment,and no noticeable side effect was found.Conclusion:It is safe and effective to treat acute attact of bronchial asthma in children by driving aerosol inhalation of pulmicort respulses and ventolin. 　　【Key words】Pulmicort；Ventolin；Aerosol inhalation；Asthma；Children 　　 　　我科自2004年9月以来应用氧气驱动雾化吸入万托林与普米克令舒联合治疗支气管哮喘（哮喘）急性发作期患儿112例，疗效满意，现报道如下。 　　 　　1 临床资料与方法 　　 　　1.1 一般资料：患儿均符合中华医学会全国儿科哮喘防治协作组制定的儿童支气管哮喘防治常规(试行) 诊断标准[1]，随机分为治疗组54例，男31例，女23例， 年龄8个月～10岁，平均(5.9±3.1)岁。其中呼吸困难31例，咳嗽40例，喘息46例，听诊有喘鸣音47例，发热20例。对照组58例，男34例，女24例，年龄6个月～10岁，平均 (5.7±3.5)岁。其中呼吸困难30例，咳嗽42例，喘息49例，听诊有喘鸣音45例，发热23例。两组患儿性别、年龄、病程、临床表现分布均匀，具有可比性(P0.05)。入院前均无呼吸衰竭、心脏衰竭并发症，排除了支气管异物等其它引起喘息的疾病。 　　1.2 方法：两组患儿均常规给予抗感染、镇咳祛痰、吸氧、镇静等综合治疗。对照组患儿在急性发作期应用地塞米松2.5 mg静脉滴入，每日1次，同时给予氨茶碱静脉滴入，3～4 mg