长效单药联合短效行抗高血压治疗临床疗效及其对随访期间收缩压变异性影响.docVIP

长效单药联合短效行抗高血压治疗临床疗效及其对随访期间收缩压变异性影响 　　【摘要】 目的：分析长效单药联合短效行抗高血压的临床疗效，并观察患者在随诊期间收缩压变化。方法：选取本院自2012年12月-2013年12月收治的60例接受抗高血压患者，采取随机数字表法分为长效单药组与短效联合组，每组各30例，观察两组患者治疗后收缩压变化情况。结果：长效单药组基线收缩压为（148.7±17.8）mm Hg，短效联合组基线收缩压为（143.5±16.9）mm Hg，两组比较差异无统计学意义（t=1.67，P0.05）。长效单药组收缩压下降值为（11.3±6.5）mm Hg，收缩压标准差为（8.6±3.6）mm Hg；短效联合组收缩压下降值为（9.4±15.4）mm Hg，收缩压标准差为（7.5±4.1）mm Hg，两组比较差异无统计学意义（P0.05）。结论：长效单药较短效联合用药在抗高血压治疗方面具有突出的临床优势，可有效降低随诊期间患者收缩压，值得推广与应用。 　　【关键词】 长效单药抗高血压； 短效联合抗高血压； 收缩压变异性 　　【Abstract】 Objective： To explore and analyze long-term line of single-drug combination of short-acting antihypertensive clinical efficacy， and systolic blood pressure were observed in patients during the follow-up impact of variability. Method： In our hospital from December 2012 to December 2013 were treated 60 patients with anti-hypertensive， and they were randomly divided into long-term monotherapy with short-acting combination group， 30 cases in each group， and observe after treatment systolic blood pressure changes. Result： The long-term monotherapy baseline systolic pressure （148.7±17.8） mm Hg， short-acting combination group for baseline systolic blood pressure （143.5±16.9） mm Hg， no significant difference between the two groups （t=1.67，P0.05）. Long-term value of systolic blood pressure decreased monotherapy group （11.3±6.5） mm Hg， systolic blood pressure standard deviation （8.6±3.6） mm Hg， systolic blood pressure decreased short-acting combined group was （9.4±5.4） mm Hg， systolic blood pressure and standard deviation （7.5±4.1） mm Hg， compared to the difference between the two groups was significant （P0.05）. Conclusion： The long-term effect of combination therapy monotherapy short of outstanding clinical advantage in terms of anti-hypertensive therapy， can effectively reduce systolic blood pressure of patients during the follow-up， worthy of promotion and application. 　　【Key words】 Long-acting antihypertensive monotherapy； Short-acting antihypertensive joint； Systolic blood pressure variability