重组人脑利钠肽治疗急性心肌梗死后心力衰竭疗效观察.docVIP

重组人脑利钠肽治疗急性心肌梗死后心力衰竭疗效观察 　　[摘要] 目的 探讨重组人脑利钠钛（rhBNP）治疗急性心肌梗死后心力衰竭的临床疗效。 方法 将我院将2007年1月~2011年2月收治的110例急性心肌梗死心力衰竭患者随机分为对照组和实验组，每组各55例。对照组在常规抗心衰治疗的基础上给予硝酸甘油，实验组在常规治疗的基础上加用rhBNP，分析比较两组患者用药后心功能改善情况、治疗前后的呼吸困难程度、整体临床状况、尿量及超声心动图检查。 结果 治疗后实验组患者的心功能改善总有效率明显优于对照组（P 0.01）；实验组用药后24 h、48 h、72 h的整体临床状况好转程度均明显高于对照组（均P 0.01）；用药后24 h实验组患者呼吸困难程度、尿量、尿量与入量的差值、EF值、Tei指数与对照组比较，差异有统计学意义（P 0.05）。 结论 rhBNP能有效改善急性心肌梗死后心力衰竭患者的呼吸困难和临床状况，提高心功能改善的总有效率，安全可靠，值得在临床推广应用。 　　[关键词] 重组人脑利钠钛；心肌梗死；心力衰竭 　　[中图分类号] R542.2+2 [文献标识码] A [文章编号] 1673-7210（2012）01（c）-0044-03 　　 　　Clinical observation on recombinant human brain natriuretic peptide (rhBNP) in the treatment of the heart failure patients after acute myocardial infarction (AMI) 　　ZENG Guoping TIAN Jingsong DUAN Shiying 　　The Central Hospital in Loudi City, Hunan Province, Loudi 417000, China 　　[Abstract] Objective To investigate the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) in the treatment of heart failure patients after acute myocardial infarction (AMI). Methods 110 cases with heart failure after AMI in our hospital from January 2006 to February 2010 were randomly divided into control group and experiment group, and each 55 cases. The control group was given nitroglycerin (NTG) on the basis of conventional treatment while the experiment group was given rhBNP on the basis of conventional treatment. The improvement of cardiac function, difficulty breathing, the overall clinical condition, urine and echocardiography were compared between the two groups. Results After treatment, the rate of improved cardiac function of the experiment group was significantly better than which of the control group (P 0.01); the clinical improved condition of 24 h 、48 h and 72 h in the experiment group was significantly higher than which of the control group (P 0.01); there were significant differences of the dyspnea, urine output, urine output and intake difference, EF, Tei index between the experiment group and the control group