阿司匹林联合阿奇霉素对慢性阻塞性肺疾病患者凝血功能影响.docVIP

阿司匹林联合阿奇霉素对慢性阻塞性肺疾病患者凝血功能影响 　　[摘要] 目的 探讨阿司匹林联合阿奇霉素对慢性阻塞性肺疾病患者凝血功能的影响。 方法 选择慢性阻塞性肺疾病合并心脏病患者80例，随机分为两组，观察组采用阿司匹林联合阿奇霉素治疗，对照组单纯采用阿司匹林治疗，比较两组治疗前后国际标准化比值，并统计血栓形成和消化道出血的发生率。 结果 观察组治疗后的国际标准化比值显著高于对照组（P0.05）。观察组的消化道出血发生率显著低于对照组（P0.05）。 结论 对阿司匹林的使用需谨慎，应在严密监测患者国际标准化比值的前提下，将阿奇霉素与阿司匹林一起服用，以减少不良药物相互作用而引起的出凝血功能障碍。 　　[关键词] 阿司匹林；阿奇霉素；凝血功能 　　[中图分类号] R563 [文献标识码] A [文章编号] 1674-4721（2014）09（c）-0077-03 　　Influence of aspirin combined with azithromycin on coagulation function in patients with chronic obstructive pulmonary disease 　　HU Yi-jun1 WU Wen-bao1 HU Yi-qin2 　　1.The Third Hospital of Fuzhou City in Jiangxi Province，Fuzhou 344000，China；2.Supervision Station of Food and Beverage Service of Fuzhou City in Jiangxi Province，Fuzhou 344000，China 　　[Abstract] Objective To explore the influence of aspirin combined with azithromycin on coagulation function in patients with chronic obstructive pulmonary disease（COPD）. Methods Eighty patients with COPD and heart disease were selected and randomly divided into two groups.Aspirin combined with azithromycin were used in observation group，while only aspirin was applied in control group.International normalized ratio（INR）before and after treatment in two groups was compared and the incidence rate of thrombus and alimentary tract hemorrhage was calculated respectively. Results After therapy，INR in observation group was obviously higher than that in control group（P0.05）.The incidence rate of alimentary tract hemorrhage in observation group was remarkably lower than that in control group（P0.05）. Conclusion It is cautious when using aspirin.At premise of close supervision of INR，administration of azithromycin and aspirin can reduce adverse drug interaction leading to blood coagulation disorder. 　　[Key words] Aspirin；Azithromycin；Coagulation function 　　阿司匹林是一种应用非常广泛的口服抗凝剂，可用于治疗和预防如心脏机械瓣膜术后和对深静脉血栓、肺栓塞、脑卒中等多种疾病，但其作用效果易受其他药物和食物的影响[1]，因此在使用时需要根据实际情况不断调整阿司匹林的剂量，将其国际标准化比值（international normalized ratio，INR）稳定于安全有效的范围内。对于慢性阻塞性肺疾病，在使用常规抗炎药物治疗效果不理想的情