顺苯磺酸阿曲库铵对兔定量药物脑电图α1α2频段影响.docVIP

顺苯磺酸阿曲库铵对兔定量药物脑电图α1α2频段影响 　　【摘要】 目的：观察顺苯磺酸阿曲库铵对兔定量药物脑电图（QPEEG）α1、α2频段的影响。方法：采用QPEEG功率谱分析法，分析兔耳缘静脉注射顺苯磺酸阿曲库铵0.3 mg/kg前后α1、α2频段功率百分比的变化。结果：与给药前比较，各脑区α1频段功率百分比在给药后各时间点（除右额在5 min、40 min稍降低）均增加，且左额、右顶、右枕及颞区在个别时间点的比较差异均有统计学意义（P0.05或P0.01）。与给药前比较，各脑区α2频段功率百分比在给药后各时间点（除左顶在5 min，左枕在10 min稍降低）均增加，且额、顶及左颞区在各时间点的比较差异均有统计学意义（P0.05或P0.01）。结论：顺苯磺酸阿曲库铵能够增加兔QPEEGα1、α2频段功率百分比。 　　【关键词】 顺苯磺酸阿曲库铵； 定量药物脑电图； 功率谱分析 　　【Abstract】 Objective：To investigate the effects of cisatracurium besylate on α1-band and α2-band of quantitative pharmaco-electroencephalography（QPEEG） in rabbits.Method：The changes of power percentage of α1-band and α2-band of QPEEG were analyzed by power spectral analysis technique in rabbits before and after intravenously injected with 0.3 mg/kg cisatracurium besylate.Result：Compared with the baseline，the power percentage of α1-band of each brain region was increased at each time point except 5 min and 40 min in the right frontal after drug infusions，and the left frontal，right parietal，right occipital and temporal areas in the individual time points，the differences had statistical significance（P0.05 or P0.01）.In contrast to the baseline，the power percentage of α2-band of each brain region were also increased at each time point except 5 min in the left parietal and 10 min in the left occipital after drug infusions，the frontal，parietal and left temporal areas in the individual time points，the differences had statistical significance（P0.05 or P0.01）.Conclusion：Cisatracurium besylate can increase the power percentage of α1-band and α2-band of QPEEG in rabbits. 　　【Key words】 Cisatracurium besylate； Quantitative pharmaco-EEG； Power spectral-analysis 　　First-author’s address：Luoyang Orthopedic-traumatological Hospital，Luoyang 471002，China 　　doi：10.3969/j.issn.1674-4985.2014.18.016 　　定量药物脑电图（quantitative pharmaco-electroencephalography，QPEEG）是药物引起脑功能变化的客观指标，已在神经病学、精神病学等方面得到广泛应用[1-4]。根据以往麻醉药对兔QPEEG影响的研究，为了消除兔接受伤害性刺激时兴奋挣扎对脑电图的干扰，后来笔者建立了肌松兔模型[5]。在肌松兔的基础上再进行麻醉药对兔QPEEG影响的研究，从而减少